藏族大骨节病血清生化指标检测及相关性分析

目的]探讨血清钙、磷、镁、碱性磷酸酶、乳酸脱氢酶、肌酐等生化指标与藏族大骨节病患者的相关性。方法]收集四川省阿坝州若尔盖地区藏族大骨节病患者295例(其中I度68例,II度89例,III度138例),同地区藏族正常对照290例,测定患者及对照的13项血清生化指标:钙(Ca)、磷(PHOS)、镁(Mg)、碱性磷酸酶(ALP)、乳酸脱氢酶(LDH)、α羟丁酸脱氢酶(HBDH)、肌酸激酶(CK)、谷丙转氨酶(ALT)、谷草转氨酶(AST)、谷氨酰转移酶(GGT)、总蛋白(TP)、白蛋白(ALB)、肌酐(Cre)。结果]藏族大骨节患者血清Mg、ALP、LDH、HBDH水平均显著高于对照组(P﹤0.05);患者血清CK、DALT、AST、GGT、Cre水平则显著低于对照组(P﹤0.05);而患者组和对照组血清Ca、PHOS、TP、ALB水平没有明显差异(P﹥0.05)。同时,患者血清ALP、LDH、HBDH、ALT和AST水平还与病情严重程度存在明显的相关性(P﹤0.05)。结论]藏族大骨节患者血清中Mg、ALP、LDH、HBDH水平显著升高,CK、ALT、AST、GGT、Cre水平则明显降低;且ALP、LDH、HBDH、ALT和AST水平与大骨节病的严重程度相关。因此,这些生化指标的检测对于大骨节患者的早期诊断和预防以及病程进展的监测具有非常重要的意义。

A STUDY ON SERUM BIOCHEMICAL PARAMETERS OF KASHIN-BECK DISEASE PATIENTS IN THE TIBETAN POPULATION

Objective]To investigate the association between serum biochemical parameters and patients with Kashin-Beck disease(KBD)in a Tibetan population.Methods]We collected 295 Tibetan KBD patients and 290 matched controls from Ruoergai county in the Aba region of Sichuan Province.The serum biochemical parameters,including Ca,PHOS,Mg,ALP,LDH,HBDH,CK,ALT,AST,GGT,TP,ALB and Cre,were determined by cyclic enzymatic test.Results]The serum Mg,ALP,LDH and HBDH levels in KBD patients were much higher than those in controls(P﹤0.05).The serum CK,ALT,AST,GGT and Cre levels of KBD patients were significantly lower than that of controls(P﹤0.05).In addition,we found that serum ALP,LDH,HBDH,ALT and AST levels were associated with the disease severity of KBD patients.Conclusion]In this study,we confirm the important role of serum Mg,ALP,LDH,HBDH,CK,ALT,AST,GGT and Cre in the development of KBD by comparing serum biochemical parameters levels between the cases and controls in a Tibetan population.