江西省部分地区结核病耐药调查情况

目的]对江西省部分地区结核病耐药调查情况进行分析,为评价近年结防工作提供参考依据。方法]按调查期间纳入的涂阳肺结核病例,对其中的143例进行体外分离菌株异烟肼、利福平、乙胺丁醇、链霉素、卡那霉素及氧氟沙星药敏试验,分析药敏试验结果。结果]143株结核分枝杆菌中,总耐药率为32.87%,耐药谱中链霉素耐药率最高;单耐药率为16.78%,耐药谱中异烟肼、链霉素耐药率较高。多耐药率为7.69%,耐药谱中以异烟肼+链霉素耐药率较高;耐多药率为8.3%,耐药谱中以异烟肼+乙胺丁醇+利福平+氧氟沙星和异烟肼+链霉素+乙胺丁醇+利福平最为常见;广泛耐药率为1.40%。结论]耐药结核病情况严重,广泛耐药结核病威胁形势严峻。

ANALYSIS OF TB DRUG RESISTANCE INVESTIGATION IN SOME AREAS OF JIANGXI

Objective]To analyze the investigation of TB drug resistance in some areas of Jiangxi province,and to provide reference for the evaluation of TB control in recent years.Methods]We included smear positive tuberculosis cases in the survey,of which 143 cases of the in vitro isolates strain got isoniazid,rifampin,ethambutol,streptomycin,kanamycin and ofloxacin susceptibility test,We analyzed the susceptibility test results.Results]Of the 143 strains of Mycobacterium tuberculosis,the total resistance rate was 32.87%.Streptomycin drug resistance was the highest rates of resistance spectrum;The single drug resistance rate was 16.78%.Isoniazid and streptomycin resistance spectrum was higher,and rate of multidrug resistance was 7.69%.The drug resistance spectrum was high to isoniazid + streptomycin.Multidrug resistance rate was 8.3%,resistance to isoniazid + ethambutol + rifampicin + isoniazid or streptomycin + ofloxacin + ethambutol+ rifampicin was the most common;The extensively drug-resistant rate was 1.40%.Conclusion]The situation of drug-resistant TB and the threat of XDR-TB were serious.