不同滴度麻疹腮腺炎风疹联合减毒活疫苗安全性观察 |
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引用本文: | 王标,陶红,叶循,王树巧,储艳,荀以标.不同滴度麻疹腮腺炎风疹联合减毒活疫苗安全性观察[J].现代预防医学,2012,39(3):720-722. |
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作者姓名: | 王标 陶红 叶循 王树巧 储艳 荀以标 |
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作者单位: | 1. 江苏省建湖县疾病预防控制中心,建湖,224700 2. 江苏省疾病预防控制中心 3. 上海生物制品研究所 |
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摘 要: | 目的]研究上海生物制品研究所的不同滴度麻疹、腮腺炎、风疹三联联合减毒活疫苗(MMR)的安全性,为疫苗的使用提供科学依据。方法]分别选择8~15月龄儿童各300名接种高滴度沪MMR、低滴度沪MMR,同时选择8~15月龄儿童150名接种北京生物所MMR疫苗作对照,进行安全性观察。结果]8~15儿童接种高滴度沪MMR疫苗、低滴度沪MMR疫苗、京MMR后,不良反应的发生率分别为17.33%、21.33%、17.33%。发热反应发生率分别依次为:15.33%,15.67%,14.67%。其中京MMR全部为中轻度发热反应,高滴度沪MMR接种后发生3例发热强反应,低滴度MMR接种后发生1例发热强反应。高、低滴度沪MMR与对照疫苗比较各项接种异常反应差异均无统计学意义。结论]不同滴度沪MMR疫苗具有与目前使用MMR疫苗相同的免疫安全性。
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关 键 词: | 麻疹-腮腺炎-风疹疫苗 安全 免疫 |
SECURITY CHECK ON DIFFERENT TITERS OF MEASLES MUMPS RUBELLA COMBINED LIVE ATTENUATED VACCINES |
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Institution: | WANG Biao,TAO Hong,YE Xun,et al.(Jianhu Center for Disease Control and Prevention in Jiangsu,Jianhu 224700,China) |
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Abstract: | Objective]To discuss the security of different titers of measles,mumps,rubella combined live attenuated vaccine(MMR)in Biological Products of shanghai institute.To provide the scientific basis for scientific use.Methods]Selected three hundred children aged 8 to 15 months to vaccinate high-titer of Shanghai MMR,low-titer of Shanghai MMR,while selected one hundred and a half children aged 8 to 15 months for MMR vaccine in the Beijing Biological Institute as controls for safety observation.Results]After 8 to 15 months children were vaccinated with high-titer of Shanghai MMR vaccine,low-titer of Shanghai MMR vaccine and Beijing MMR,the incidence of adverse reactions was 17.33%,21.33% and 17.33%,respectively.And incidence of fever was 15.33%,15.67%,14.67% respectively.Among them,all reactions to Beijing MMR vaccination were mild fever,3 cases of strong reaction of fever with high-titer of Shanghai MMR vaccination.One case of fever strong reaction occurred after low-titer of Shanghai MMR vaccination.The abnormal responses of high and low titers of Shanghai MMR vaccination compared with the control vaccine were not statistically significant.Conclusion]The different titers of Shanghai MMR vaccine have the same immunization safety with vaccine currently used. |
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Keywords: | Measles-mumps-rubella vaccine Security Immunity |
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