| tRNA来源的小RNA(tRF)的生物学功能及在癌症中的作用 |
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| 引用本文： | 许琳枫,王显仪,柴彬淑,马中良. tRNA来源的小RNA(tRF)的生物学功能及在癌症中的作用[J]. 转化医学杂志, 2021, 10(3): 191-196 |
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| 作者姓名： | 许琳枫 王显仪 柴彬淑 马中良 |
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| 作者单位： | 上海大学生命科学学院，非编码RNA与癌症实验室 |
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| 基金项目： | 上海市科委“创新行动计划”资助（NO: 20S11901300） |
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| 摘 要： | 来源于tRNA的RNA片段(tRNA-derived Fragments,tRFs)是一种非编码RNA(non-coding RNA,ncRNA),长度约为14-35 nt.tRFs源自前体tRNA(Pre-tRNA)或成熟tRNA,有如下几种主要类型:tRF-1,tRF-2,tRF-3,tRF-5和i-tRF,其在生...
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| 关 键 词： | 非编码RNA tRNA tRFs 肿瘤发生 |
Biological function of tRNA-derived small fragments (tRF) and its role in cancer |
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| XU Linfeng,WANG Xianyi,CHAI Binshu,MA Zhongliang. Biological function of tRNA-derived small fragments (tRF) and its role in cancer[J]. Translational Medicine Journal, 2021, 10(3): 191-196 |
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| Authors: | XU Linfeng WANG Xianyi CHAI Binshu MA Zhongliang |
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| Abstract: | tRNA-derived fragments (tRFs) are non-coding RNA with a length of about 14-35 nt. tRFs are derived from precursor tRNA(pre-tRNA) or mature tRNA, and have the following main types: tRF-1, tRF-2, tRF-3, tRF-5 and i-tRF, which have the mechanisms of regulating gene expression and inhibiting protein translation in life process, and can also serve as biomarkers and therapeutic targets in tumor diagnosis and treatment. In this paper, the biological function of tRFs and its research progress in cancer were systematically reviewed. |
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| Keywords: | Non-coding RNA tRNA tRFs Tumorigenesis |
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