Magnetic resonance microimaging for noninvasive quantification of myocardial function and mass in the mouse |
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Authors: | Jan Ruff Frank Wiesmann Karl-Heinz Hiller Sabine Voll Markus von Kienlin Wolfgang R. Bauer Eberhard Rommel Stefan Neubauer Axel Haase |
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Abstract: | The purpose of this work was to develop high-resolution cardiac magnetic resonance imaging techniques for the in vivo mouse model for quantification of myocardial function and mass. Eight male mice were investigated on a 7-Tesla MRI scanner. High-quality images in multiple short axis slices (in-plane resolution 117 μm2, slice thickness 1 mm) were acquired with an ECG-gated cine sequence. Left ventricular end-diastolic and end-systolic volumes and mass were calculated from segmented slice volumes. There was precise agreement of left ventricular mass determined ex vivo and by MRI. lntraobserver (5%) and interobserver (5%) variability of in vivo MR measurements were low. |
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Keywords: | mouse heart magnetic resonance imaging myocardial mass myocardial function |
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