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Severe chronic active giftein-Barr virus infection accompanied by virus-associated hemophagocytic syndrome,cerebellar ataxia and encephalitis
Authors:SHU-ICHI YAMASHITA  CHISA MURAKAMI  YOICHIRO IZUMI  HITOSHI SAWADA  YOSHIHIRO YAMAZAKI  TADA-AKI YOKOTA  NOBUHIRO MATSUMOTO  SHIGERU MATSUKURA
Abstract:We present a rare case of chronic active giftein-Barr virus (EBV) infection showing various clinical outcomes. A 26-year-old man was admitted to our hospital due to persistent fever and dyspnea. Serologic response of the patient to EBV indicated chronic active infection. He showed pleuritis, parotitis, chronic hepatic dysfunction, disseminated intravascular coagulation, virus associated hemophaghocytic syndrome, acute rhabdomyolysis, acute renal failure, acute cerebellar ataxia, encephalitis and multiple brain abscesses. None of acyclovir, gancyclovir, prednisolone or interleukin-2 was effectual to abolish those abnormalities. This is the first report of transient cerebellar ataxia which aggravated to panencephalitis associated with chronic EBV infection.
Keywords:acute renal failure  infectious mononucleosis  in situ hybridization                 interleukin-2
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