The prognostic effect of PNN in digestive tract cancers and its correlation with the tumor immune landscape in colon adenocarcinoma |
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Authors: | Hui Zhang Ming Jin Meng Ye Yanping Bei Shaohui Yang Kaitai Liu |
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Affiliation: | 1. Department of Radiation Oncology, The Lihuili Hospital, Ningbo Medical Center, Ningbo China ; 2. Department of Oncology and Hematology, The Affiliated Hospital of Medical School of Ningbo University, Ningbo China ; 3. Department of General Surgery, The Lihuili Hospital, Ningbo Medical Center, Ningbo China |
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Abstract: | BackgroundThe present study investigated the expression, mutation, and methylation profile of PNN and its prognostic value in digestive tract cancers. The disparities in signaling pathways and the immune landscape in colon adenocarcinoma (COAD) based on PNN expression were specifically explored.MethodsThe expression, mutation, methylation levels of PNN, and survival data in esophageal cancer, gastric adenocarcinoma, COAD, and rectal adenocarcinoma were evaluated using several bioinformatic databases. Gene Ontology (GO) enrichment analysis and gene set enrichment analysis (GSEA) were performed to investigate the enriched biological functions and pathways in COAD. Several acknowledged bioinformatic algorithms were employed to assess the correlation between PNN expression and the tumor immune landscape in COAD.ResultsPNN was upregulated and remarkably related to tumor stage in digestive tract cancers. High expression of PNN was positively associated with poor progression‐free survival and overall survival time, specifically in COAD. PNN expression was identified as an independent prognostic factor in COAD. GO and GSEA analyses revealed that PNN participates in multiple biological processes underlying carcinogenicity in COAD. Further investigation showed that PNN expression was significantly associated with tumor‐infiltrating immune cells, immune cell functions, and several immune checkpoints in COAD. The PNN low expression group had a lower tumor immune dysfunction and exclusion (TIDE) score and a higher immunophenoscore (IPS), indicating a better response to immunotherapy.ConclusionPNN was highly expressed in digestive tract cancers and could act as an independent prognostic factor and a response predictor for immunotherapy in COAD. |
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Keywords: | colon adenocarcinoma immune landscape PNN prognosis The Cancer Genome Atlas |
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