Differentiation of PC12 pheochromocytoma cells by sodium butyrate |
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| Affiliation: | 1. Department of Biomedical Sciences, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan;2. Center for Healthy and Aging Research, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan;3. Department of Physiology and Pharmacology, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan;4. Heart Failure Center, Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Keelung, Taiwan;5. Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan;1. Department of Orthopedic Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China;2. Department of Orthopaedic Surgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China;3. Fujian Provincial Institute of Orthopedics, Fuzhou, China;4. Department of Orthopedic Surgery, Affiliated Hospital of Putian University, Putian,China;5. Department of Pediatric Orthopedic Surgery, The First Affiliated Hospital of Xiamen University, Xiamen, China |
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| Abstract: | PC12 pheochromocytoma cells cease dividing and show increased cell-cell and cell-substratum adhesion in response to treatment with sodium butyrate. These changes are accompanied by the rapid appearance of neuron-specific enolase, an APUD cell marker. However, neurofilament proteins, markers for neuronal differentiation, are not induced. These results suggest that sodium butyrate induces differentiation in the PC12 cell line, perhaps along the chromaffin cell pathway. |
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