甲胎蛋白和癌胚抗原在肿瘤肝癌临床检测中的应用

目的评价血清甲胎蛋白（AFP）及癌胎抗原（CEA）在原发性肝癌（PHC）临床诊断中的应用及其价值。方法对201例原发性肝癌（PHC），73例肝硬化和54例健康对照者，用微粒子化学发光免疫分析法测定血清AFP和CEA。结果PHC患者的AEP水平显著高于肝硬化的患者及健康体检者。肝硬化组的AEP也有一定程度的升高。原发性肝癌AFP极度增高，可达到6027μg／L肝硬化患者的血清AFP亦有一定程度的提高，可达到1880μg／L。当肝病患者以AFP〉20μg／L作为阈值诊断原发性肝癌时，其灵敏度为73．13％，特异性达38．36％，以AFP〉400μg／L作为阈值诊断原发性肝癌时，其灵敏度为44．28％，特异性达80．43％。CEA以PHC组最高，为（13．4±32．6）μg／L，明显比肝硬化和健康对照组高（P〈0．01）。结论AFP升高对HCC诊断具有较强的提示作用，结合CEA值的升高用于高危人群筛查及对于AFP阳性患者术后随访具有重要作用。

Armor embryo protein and cancer embryo antigen in tumor liver cancer clinical examination application

Objective To evaluate the usefulness of serum alpha-fetoprotein(AFP) and carcinoemb-ryonic antigen (CEA)carcinoma in clinical diagnosis and screening for primary hepatic carcinoma (PHC).Methods Totally 201 PHC patients,73 liver cirrhosis patients,and 54 healthy subjects were enrolled in this study.All of the sample were measured by microparticle chemiluminescent immunoassay.Results The serum AFP level was significantly higher in PHC patients than in liver cirrhosis patients and healthy subjects.The serum AFP level was increase in liver cirrhosis patients too.The serum AFP level was extremely increased in PHC patients,it could be up to 6027 μg/L,and it also increased in liver cirrhosis patients,it could be up to 1880 μg/L.Sensitivity and specificity of AFP at 20 μg/L cut-off was 73.13% and 38.36%.Sensitivity and specificity of AFP at 400 μg/L cut-off was only 44.28% and 80.43%.The serum CEA level was( 13.4 ± 32.6) μg/L,which was significantly higher than the other two group (P ＜ 0.01 ).Conclusion AEP increase on strong HCC diagnosed with hints of function,increase the CEA value for high-risk patients with positie screening for AFP and plays on important role in the follow-up.