35～50岁女性脂肪组织分布对血脂和体内氧化应激水平的影响

目的研究女性脂肪组织含量和分布对体内氧化应激水平的影响。方法双能X线吸收法(DEXA)测定35~50岁女性全身各部位体脂成分分布,测定血脂总胆固醇(TC)、总甘油三酯(TC)和血清超氧化物歧化酶(SOD)、谷胱甘肽还原酶(GR)以及肿瘤坏死因子-α(TNF-α)含量,分析体脂成分与血脂、抗氧化物质的相关关系。结果(1)血清TG、TC、TNF-α水平均表现为肥胖组>超重组>正常体重组,而血清SOD、GR含量则表现为肥胖组<超重组<正常体重组。(2)BMI、腹部脂肪重量均与血清SOD、GR成负相关关系,而与TNF-α含量呈正相关关系;而全身脂肪重量、外周(四肢和头部)脂肪重量与血清SOD、GR、TNF-α水平无相关关系。(3)腹部体脂百分比也与血脂呈正相关关系,与血清SOD、GR呈负相关关系,与TNF-α呈正相关关系;外周脂肪百分比与TG、TC呈负相关,而与血清SOD、GR、TNF-α水平无相关。(4)偏相关分析结果发现,腹部脂肪含量与血清SOD、GR呈负相关,与TNF-α正相关。结论腹部脂肪过度聚集可能引起体内氧化应激状态,同时导致血脂上升。

Effect of body fat distribution on plasma lipids and oxidative stress in women aged 35 to 50 years

OBJECTIVE: To evaluate the effect of body fat composition and distribution on plasma lipid profile and oxidative stress in middle-aged women. METHODS: 181 healthy Chinese women (age ranged from 35 to 50 years) were recruited. Their body fat mass and distribution were measured by dual-energy x-ray absorptiometry (DEXA). The oxidative status were evaluated by determination of serum levels of tumor necrosis factor-alpha (TNF-alpha), Glutathione peroxidase (GR) and Superoxide dismutase (SOD) and the plasma lipids, including total cholesterol (TC) and Triglycerides (TG) were also measured. RESULTS: (1) Plasma TG and TC levels and serum TNF-alpha levels were significantly higher in overweight and obese women, while serum SOD and GR activity were significantly in these 2 groups, compared to normal-weight women. (2) Serum SOD and GR activity decreased, and TNF-alpha level increased with body mass index (BMI) and abdominal fat mass, as shown by linear correlation analysis. No correlation was found between serum oxidative indices, lipids and total body and subcutaneous fat. (3) The percentage of abdominal fat mass had positive correlations with the SOD and GR, and negative correlations with TNF-alpha. Whereas the percentage of subcutaneous fat mass did not have correction relationship with TNF-alpha, SOD, GR, but had negative correlation with TG and TC. (4) By the partial correlations analysis, abdominal fat mass were found to be negatively correlated with serum SOD and GR, and positively correlated with serum TNF-alpha. CONCLUSION: Abdominal fat accumulation could be the marker of the oxidative stress and would elevate serum triglycerides and total cholesterols.