血清前白蛋白检测在维持性血液透析患者中的意义

目的探讨维持性血液透析（MHD）患者血清前白蛋白（PA）检测的意义。方法选择行MHD的尿毒症患者92例，根据年龄分为青年组34例、中年组35例及老年组23例。检测MHD患者血清PA、血浆自蛋白（Alb）、超敏C反应蛋白（hs-CRP）、血红蛋白（Hb）等。以hs-CRP水平评价慢性炎症的状态。结果hs-CRP升高者的血清PA水平显著低于hs-CRP正常者（P〈0．01）。血清PA水平与C反应蛋白（CRP）呈负相关（r=-0．286，P=0．007）。结论血液透析患者普遍存在慢性炎症状态，炎症反应在营养不良中起着重要作用。

Clinical implication of detection of serum prealbumin among maintenance hemodialysis patients

Objective To investigate the effect of haemodialysis on serum levels of prealbumin. （PA） in patients with uraemia. Methods Patients undergoing maintenance haemodialysis （MHD） since April 2010 were divided into three groups according to their ages：group Ⅰ, 34 young adults （18-44 years old）;group Ⅱ,35 adults（45-59 years old）;and group Ⅲ,23 senior adults（68-88 years old）. Serum PA, albumin（Alb）, high sensitive C-reactive protein （hs-CRP）, hemoglobin and ferritin were determined in 92 MHD patients. Hs-CRP level was used to evaluate microinflammatory status. Results Patients with elevated hs-CRP levels had lower serum PA levels than those with the normal range of serum hs-CRP （P〈0. 01）. Serum PA levels had a negative correlation with hs-CRP levels （r= - 0. 286, P = 0. 007）. Conclusions Inflammatory reaction is a common status among chronic hemodialysis patients, and it plays an important role in the formation of malnutrition.