| 丹酚酸B防治肾功能衰竭作用机制的研究进展 |
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| 引用本文： | 王小娇,况刚,廖如贤,张昌碧. 丹酚酸B防治肾功能衰竭作用机制的研究进展[J]. 现代药物与临床, 2022, 37(11): 2665-2668 |
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| 作者姓名： | 王小娇 况刚 廖如贤 张昌碧 |
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| 作者单位： | 重庆市大足区人民医院 重症医学科, 重庆 402360 |
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| 基金项目： | 重庆市科卫联合医学科研项目（2018ZDXM028） |
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| 摘 要： | 肾功能衰竭是各种慢性肾脏病的终末阶段，可发生肾组织进行性不可逆性损伤。丹酚酸B是丹参中主要水溶性化合物，能够抗肾间质纤维化、抗脂质氧化反应、抗炎症反应、改善肾脏血液循环、抗细胞凋亡、抗缺血再灌注损伤、保护血管内皮细胞功能。综述了丹酚酸B防治肾功能衰竭的作用机制，以期为丹酚酸B的临床使用价值提供参考。
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| 关 键 词： | 丹酚酸B 肾功能衰竭 肾间质纤维化 脂质氧化反应 炎症反应 |
| 收稿时间： | 2022-08-16 |
Research progress on mechanism of salvianolic acid B in prevention and treatment of renal failure |
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| WANG Xiao-jiao,KUANG Gang,LIAO Ru-xian,ZHANG Chang-bi. Research progress on mechanism of salvianolic acid B in prevention and treatment of renal failure[J]. Drugs & Clinic, 2022, 37(11): 2665-2668 |
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| Authors: | WANG Xiao-jiao KUANG Gang LIAO Ru-xian ZHANG Chang-bi |
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| Affiliation: | Department of Intensive Care Medicine, The People''s Hospital of Dazu, Chongqing, Chongqing 402360, China |
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| Abstract: | Renal failure is the end stage of various chronic kidney diseases, which can cause progressive and irreversible damage to renal tissue. Salvianolic acid B is the main water-soluble compound in Salviae Miltiorrhizae Radix et Rhizoma, which can resist renal interstitial fibrosis, resist lipid oxidation reaction, anti-inflammatory response, improve renal blood circulation, resist apoptosis, resist ischemia-reperfusion injury, and protect vascular endothelial cell function. This paper reviews the mechanism of salvianolic acid B in preventing and treating renal failure, in order to provide reference for the clinical use value of salvianolic acid B. |
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| Keywords: | salvianolic acid B renal failure renal interstitial fibrosis lipid oxidation reaction inflammatory reaction |
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