Elevated c-Src and c-Yes expression in malignant skin cancers |
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| Authors: | Jang Hyun Lee Jae-Kyung Pyon Dong Wook Kim Sang Han Lee Hae Seon Nam Chul Han Kim Sang Gue Kang Yoon Jin Lee Mi Youn Park Dong Jun Jeong Moon Kyun Cho |
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| Institution: | 1.Department of Plastic and Reconstructive surgery, Hanyang University Guri Hospital, Guri, Korea;2.Department of Plastic and Reconstructive surgery, School of medicine, Sungkyunkwan University, Seoul, Korea;3.Molecular Cancer Research Center, College of Medicine, Soonchunhyang University, Chunan, Korea;4.Department of Dermatology, National Medical Center, Seoul, Korea;5.Department of Dermatology, College of Medicine, Soonchunhyang University, Seoul, Korea |
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| Abstract: | AbstractsBackgroundSrc family kinases (SFKs) play an important role in cancer proliferation, survival, motility, invasiveness, metastasis, and angiogenesis. Among the SFKs, c-Src and c-Yes are particularly over-expressed or hyper-activated in many human epithelial cancers. However, only a few studies have attempted to define the expression and role of c-Src and c-Yes in cutaneous carcinomas.ObjectivesTo investigate the expression of c-Src and c-Yes in cutaneous carcinomas to include malignant melanoma (MM), squamous cell carcinoma (SCC) and basal cell carcinoma (BCC).MethodsWe examined 6 normal skin tissues and 18 malignant skin tumor tissues using western blotting for the expression of c-Src and c-Yes. In another set, 16 specimens of MM, 16 SCCs and 16 BCCs were analyzed for the expression of c-Src and c-Yes using immunohistochemical staining.ResultsWestern blotting showed that c-Src was expressed in all malignant skin tumors, but not in normal skin, while c-Yes was expressed in MM and SCC, but not in BCC and normal skin. Immunohistochemical staining results of c-Src and c-Yes in MM, SCC, and BCC mirrored those of the western blot analysis.Conclusionsc-Src, rather than c-Yes, plays a key role in the proliferation and progression of malignant skin cancers. |
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