单倍体移植治疗白血病疗效观察

目的探讨单倍体移植治疗白血病的疗效。方法在单倍体移植时采用阿糖胞苷（Ara-c）、马利兰（Bu）、环磷酰胺（CTX）、甲基环己亚硝脲（Me-CCNU）联合作为预处理方案,用CTX、重组人粒细胞集落刺激因子（rhG-CSF）、环孢素A（CSA）、麦考酚酸酯（MMF）、抗胸腺细胞球蛋白（ATG）、白细胞介素11（IL-11）及甲氨蝶呤（MTX）联合预防急性移植物抗宿主病（aGVHD）,治疗7例白血病;结果 7例患者完全植入,白细胞〉1.0×109/L中位时间为16.9 d,Ⅲ~Ⅳ度aGVHD发生率为14.3%,中位随访时间25.6个月,无复发,至今仍存活。结论单倍体移植治疗白血病时,用Ara-c、Bu、CTX、Me-CCNU联合作为预处理方案,用CTX、rhG-CSF、CSA、MMF、ATG、IL-11及MTX联合预防aGVHD是安全、有效的。

Clinical observation of patients with leukemia treated with haploidentical hematopoietic stem cell transplantation

Objective To study the effect of haploidentical hematopoietic stem cell transplantation as a treatment of leukemia.Methods 7 cases of leukemia were treated treated with haploidentical hematopoietic stem cell transplantation.Cytosine arabinoside（Ara-c）,busulphan（Bu）,cyclophosphamide（CTX） and methyl ccnu（Me-CCNU） were used to precondition patients.CTX,rhG-CSF,cyclosporine A（CSA）,mycophenolate mofetil（MMF）,anti-thymocyte globulin（ATG）,IL-11 and methotrexate（MTX） were used to prevent acute graft versus host diseases.Results All patients achieved complete engraftment.The median times of neutrophil recovery 〉1.0×10^9/L were 16.9 days after transplantation.The incidence of grade Ⅲ～Ⅳ GVHD was 14.3%.All patients survived disease-free with a median follow-up of 25.6 months.Conclusions Haploidentical hematopoietic stem cell transplantation is safe and effective for treating leukemia,with Ara-c,Bu,CTX,Me-CCNU as preconditioning,CTX,rhG-CSF,CSA,MMF,ATG,IL-11 and MTX as prophylaxis of aGVHD.