Acute and subacute toxicity study of 1,8-cineole in mice |
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| Authors: | Jiao Xu Zhi-Qiang Hu Chuan Wang Zhong-Qiong Yin Qin Wei Li-Jun Zhou Li Li Yong-Hua Du Ren-Yong Jia Mei Li Qiao-Jia Fan Xiao-Xia Liang Chang-Liang He Li-Zi Yin |
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| Affiliation: | 1.College of Veterinary Medicine, Sichuan Agricultural University, Ya’an, 625014, China;2.Key Lab of Southwest Special Economic Plant Protection & Utilization, Yibin College, Yibin, 644000, China;3.College of Forestry, Sichuan Agricutural University, Ya’an, 625014, China;4.Leshan Vocational & Technical College, Leshan, 614000, China |
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| Abstract: | The effects of acute and subacute toxicity of 1,8-cineole in Kunming mice were studied. After acute oral administration, the LD50 value (95% CL) was 3849 mg/kg (3488.8~4247.1 mg/kg). In the subacute toxicity study, there were no significant differences in body weight and relative organ weight between the control group and 1,8-cineole treatment groups. The histopathological examinations showed that granular degeneration and vacuolar degeneration appeared in liver and kidney tissue after administration of high dose of 1,8-cineole. Under electron microscopy, a series of ultrastructural changes were observed: The electron microscopy assays indicated that the influence of 1,8-cineole on the target organ at the subcellular level were mainly on the mitochondria, endoplasmic reticulum and other membrane type structure of liver and kidney. |
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| Keywords: | 1 8-cineole toxicity histopathology ultrastructural changes mice |
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