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High Plasma Homocysteine Increases Risk of Metabolic Syndrome in 6 to 8 Year Old Children in Rural Nepal
Authors:Mohsin Yakub  Kerry J. Schulze  Subarna K. Khatry  Christine P. Stewart  Parul Christian  Keith P. West  Jr.
Affiliation:1.Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA; E-Mails: (M.Y); (P.C); (K.P.W);2.Nepal Nutrition Intervention Project-Sarlahi, Tripureswor, Kathmandu 45104, Nepal; E-Mail: ;3.Program in International and Community Nutrition, University of California, Davis, CA 95616, USA; E-Mail:
Abstract:Little attention has been given to the association of plasma homocysteine (Hcy) and metabolic syndrome (MetS) in children. We have evaluated the risk of MetS with plasma Hcy in a cohort of 6 to 8 year old rural Nepalese children, born to mothers who had participated in an antenatal micronutrient supplementation trial. We assessed Hcy in plasma from a random selection of n = 1000 children and determined the relationship of elevated Hcy (>12.0 μmol/L) to MetS (defined as the presence of any three of the following: abdominal adiposity (waist circumference ≥ 85th percentile of the study population), high plasma glucose (≥85th percentile), high systolic or diastolic blood pressure (≥90th percentile of reference population), triglyceride ≥ 1.7 mmol/L and high density lipoprotein < 0.9 mmol/L.) and its components. There was an increased risk of low high-density lipoproteins (HDL), [odds ratios (OR) = 1.77, 95% confidence intervals (CI) = 1.08–2.88; p = 0.020], high blood pressure [OR = 1.60, 95% CI = 1.10–2.46; p = 0.015] and high body mass index (BMI) [OR = 1.98, 95% CI = 1.33–2.96; p = 0.001] with elevated Hcy. We observed an increased risk of MetS (OR = 1.75, 95% CI = 1.06–2.90; p = 0.029) with elevated Hcy in age and gender-adjusted logistic regression models. High plasma Hcy is associated with increased risk of MetS and may have implications for chronic disease later in life.
Keywords:metabolic syndrome   homocysteine   Nepal
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