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Chronic Wasting Disease Agents in Nonhuman Primates |
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| Authors: | Brent Race Kimberly D. Meade-White Katie Phillips James Striebel Richard Race Bruce Chesebro |
| Affiliation: | National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA |
| Abstract: | Chronic wasting disease is a prion disease of cervids. Assessment of its zoonotic potential is critical. To evaluate primate susceptibility, we tested monkeys from 2 genera. We found that 100% of intracerebrally inoculated and 92% of orally inoculated squirrel monkeys were susceptible, but cynomolgus macaques were not, suggesting possible low risk for humans. |
| Keywords: | Chronic wasting disease prion transmissible spongiform encephalopathy species barrier transmission non-human primate squirrel monkey cynomolgus macaque |