The efficiency of glutamate uptake differs between neonatal and adult cortical microvascular endothelial cells |
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Authors: | Maryline Lecointre Michelle Hauchecorne Armelle Chaussivert Stéphane Marret Philippe Leroux Sylvie Jegou Isabelle Leroux-Nicollet Bruno J Gonzalez Vincent J Henry |
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Institution: | 1.ERI28 NeoVasc, Laboratory of Microvascular Endothelium and Neonate Brain Lesions, Normandy University, Institute for Research and Innovation in Biomedicine, Rouen, France;2.Department of Neonatal Pediatrics and Intensive Care, Rouen University Hospital, Rouen, France |
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Abstract: | Glutamate transporters (excitatory amino-acid transporters (EAATs)) are essential for brain homeostasis. While previous studies indicate that the vascular endothelium contributes to glutamate efflux in the adult brain, little information is available regarding glutamate uptake in the immature brain. The present study shows a differential expression pattern of EAATs between cortical microvessels in adults and newborns. In addition, adult cortical endothelial cells take up glutamate more efficiently than neonatal cells. Our findings indicate age-specific changes in extracellular glutamate regulation by brain endothelial cells, suggesting differences in the efficiency of glutamate efflux during an excitotoxic process that, in turn, may contribute to age-specific brain vulnerability. |
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Keywords: | brain development endothelium excitotoxicity glutamate immunohistochemistry |
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