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Persistence and Complex Evolution of Fluoroquinolone-Resistant Streptococcus pneumoniae Clone |
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| Authors: | Debby Ben-David Mitchell J. Schwaber Amos Adler Samira Masarwa Rotem Edgar Shiri Navon-Venezia David Schwartz Nurith Porat Tali Kotlovsky Nikolay Polivkin Irina Weinberg Avraham Lazary Nissim Ohana Ron Dagan |
| Affiliation: | National Center for Infection Control, Tel Aviv, Israel (D. Ben-David, M.J. Schwaber, A. Adler, S. Masarwa, R. Edgar, S. Navon-Venezia); ;Sourasky Medical Center, Tel Aviv (D. Schwartz, N. Porat, T. Kotlovsky, R. Dagan); ;Ben-Gurion University of the Negev, Beer-Sheva (N. Porat, R. Dagan); ;Reuth Medical Center, Tel Aviv (N. Polivkin, I. Weinberg, A. Lazary, N. Ohana) |
| Abstract: | Prolonged outbreaks of multidrug-resistant Streptococcus pneumoniae in health care facilities are uncommon. We found persistent transmission of a fluroquinolone-resistant S. pneumoniae clone during 2006–2011 in a post–acute care facility in Israel, despite mandatory vaccination and fluoroquinolone restriction. Capsular switch and multiple antimicrobial nonsusceptibility mutations occurred within this single clone. The persistent transmission of fluoroquinolone-resistant S. pneumoniae during a 5-year period underscores the importance of long-term care facilities as potential reservoirs of multidrug-resistant streptococci. |
| Keywords: | Streptococcus pneumoniae fluoroquinolones antimicrobial drug resistance long-term acute care hospital clonal evolution bacteria |