Optimal Frequency to Screen Celiac Disease amongst Patients with Type 1 Diabetes Mellitus: A Multicenter Study |
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| Affiliation: | 1. Neonatal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran;2. Department of Pediatric Endocrinology and Metabolism, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;3. Diabetes Research Center, Mazandaran University of Medical Sciences, Sari, Iran;4. Department of Pediatric, Non-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran;5. Metabolic Liver Disease Research Center, Isfahan University of Medical Sciences, Isfahan, Iran;6. Department of Pediatric, Jiroft University of Medical Sciences, Jiroft, Iran;7. Department of Pediatric Endocrinology and Metabolism, Mashhad University of Medical Sciences, Mashhad, Iran;8. Department of Pediatric Diseases, Akbar Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;9. Department of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;10. Pediatric Endocrinologist, Shafa Hospital, Kerman University of Medical Sciences, Kerman, Iran;1. Department of Population Medicine, College of Medicine, QU Health, Qatar University, Doha, Qatar;2. Medicine Department, Hamad Medical Corporation, Doha, Qatar;3. Department of Clinical Research, Primary Health Care Corporation, Doha, Qatar;4. The Centre for Research into Evidence Based Practice, Bond University, Gold Coast, Queensland, Australia;5. UQ Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Herston, Queensland, Australia;6. Qatar Metabolic Institute and Medicine Department, Hamad Medical Corporation, Doha, Qatar;1. DAP-Cat group, Unitat de Suport a la Recerca Barcelona Ciutat, Institut Universitari d''Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol), Barcelona, Spain;2. Primary Health Care Center Ronda Prim, Gerència d’Àmbit d''Atenció Primària Metropolitana Nord de Barcelona, Institut Català de la Salut, Mataró, Spain;3. Primary Health Care Centre Sant Roc, Gerència d’Àmbit d''Atenció Primària Metropolitana Nord de Barcelona, Institut Català de la Salut, Mataró, Spain Catalan Health Institute, Badalona, Spain;4. Primary Health Care Centre Ca n’Oriac, Gerència d’Àmbit d''Atenció Primària Metropolitana Nord de Barcelona, Institut Català de la Salut, Sabadell, Spain;5. Primary Health Care Centre Raval Sud, Gerència d’Àmbit d''Atenció Primària Barcelona Ciutat, Institut Català de la Salut, Barcelona, Spain;6. Primary Health Care Centre El Carmel, Gerència d’Àmbit d''Atenció Primària Barcelona Ciutat, Institut Català de la Salut, Sant Adrià de Besòs, Spain;7. Universitat Internacional de Catalunya, Epidemiologia i Salut Pública, Sant Cugat, Spain;8. Pharmacology Department, Universitat Autònoma de Barcelona (UAB), Cerdanyola del Vallès, Spain;9. Fundació Institut d''Investigació en Ciències de la Salut Germans Trias i Pujol (IGTP), Badalona, Spain;10. Primary Health Care Center La Mina, Gerència d’Àmbit d''Atenció Primària Barcelona Ciutat, Institut Català de la Salut, Sant Adrià de Besòs, Spain;11. Innovation office at Institut Català de la Salut, Barcelona, Spain;12. Department of Endocrinology & Nutrition, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain;13. Departament of Medicine, University of Vic - Central University of Catalonia, Vic, Spain;14. CIBER of Diabetes and Associated Metabolic Diseases (CIBERDEM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain;1. South Karelia Social and Health Care District, Finland;2. Center for Life Course Health Research, University of Oulu, Oulu, Finland;3. Medical Research Center, Oulu University Hospital, Oulu, Finland;4. SILK, Department of Ophthalmology, Faculty of Medicine and Health Technology, Tampere University, PL 100, 33014 Tampere, Finland;5. Tays Eye Centre, Tampere University Hospital, Tampere, Finland;6. Department of Endocrinology, Abdominal Center, Helsinki University Hospital, Helsinki, Finland;7. Healthcare and Social Services of Selänne, Pyhäjärvi, Finland;8. Public Health Promotion Unit, Finnish Institute for Health and Welfare, Helsinki, Finland;9. Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia;1. Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK;2. Royal College of General Practitioners (RCGP) Research and Surveillance Centre (RSC), London, UK;3. Diabetes Research Centre, University of Leicester, Leicester, UK;4. Department of Clinical and Experimental Medicine, University of Surrey, Guildford, UK;5. Department of Statistical Sciences, University of Bologna, Italy;1. Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran;2. Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran |
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| Abstract: | AimsCeliac disease (CD) is frequent amongst patients with type 1 diabetes mellitus (T1DM). Since there is a disagreement on the optimal interval and frequency to perform screening tests for CD among diabetic patients, this study aimed to evaluate these issues amongst patients with T1DM.MethodsThis retrospective cohort study was conducted in seven referral diabetic centers in different cities of Iran from January 2020 to January 2021. Data belonging to 106 patients who were affected by both T1DM and CD was collected. The time interval between CD diagnosis and diabetes (IBCD), the age of diabetes onset, and any associated diseases, symptoms, and family history of T1DM and CD were recorded and analyzed.ResultsResults show that 45% of the patients with CD were diagnosed during the first year of diabetes onset; furthermore, 18% and 16% of the patients with CD were diagnosed in the second or third year after being diagnosed with diabetes. In addition, another 18% of patients with CD were diagnosed during the fourth till the eighth year after diabetes onset. Moreover, there was a negative relationship between the age of T1DM diagnosis and IBCD. Most participants were asymptomatic at the time of CD diagnosis.ConclusionsScreening tests to detect CD amongst patients with T1DM should continue for at least eight years after the initial T1DM diagnosis, especially those affected at a younger age. |
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| Keywords: | Celiac disease Diabetes Mellitus Type 1 Transglutaminase Autoimmune Diseases |
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