脑发育异常性癫痫脑组织的MDR-1、MRP和GFAP表达一例并文献复习

目的：观察灰质异位性难治性癫痫中多药耐药基因蛋白（MDR-1）、耐药基因相关蛋白（MRP）及胶质纤维酸性蛋白（GFAP）在发育异常性脑组织中的表达情况。方法：对确诊为脑灰质异位性症状性癫痫患者手术切除下病灶组织行免疫组化染色，观察脑组织中MDR-1、MRP及GFAP的表达情况。结果：在手术切除的病灶组织中，除一些增生性的星形胶质细胞同时具上述三种蛋白的阳性标记外，在一些异形的神经元内同时还存在有MDR-1和MRP的阳性表达。结论：灰质异位性难治性癫痫中MDR-1、MRP及GFAP不仅可在一些反应性的星形胶质细胞中表达，而且还可在一些发育异常的异形神经元中表达。

The expression of MDR-1, MRP and GFAP in the resected brain tissue from a case of cortical dysplasia with intractable epilepsy

Objective To observe the expression of MDR 1,MRP and GFAP in the resected brain tissues of corical dysplasia. Methods The brain tissue was resected in a clinical case who was diagnosed as cortical dysplasia with intractable epilepsy, The specimen was stained immunohistochemically to observe the expression of MDR 1, MRP and GFAP. Results An over expression of immunoreactivities for MDR 1 and MRP was found at both reactive astrocyte and some giant dysplastic neurons, while the overexpression of GFAP could only be found at some reactive astrocyte. Conclusions The overexpression of MDR 1 and MRP can be found at some giant dysplasia neurons in patients of cortical dysplasia with intractable epilepsy.