MMP-2、MMP-9和TIMP-1在胃癌组织中的表达及其与临床病理特点和预后的关系

目的：探讨基质金属蛋白酶（MMP-2、MMP-9）和金属蛋白酶组织抑制剂（TIMP-1）在胃癌中的表达及与临床病理特点和预后的关系。方法：应用免疫组织化学技术和形态定量分析方法。结果：MMP-2、MMP-9在胃癌基质中有表达，明显高于癌旁正常组织（P<0.01）；TIMP-1分布于癌巢周边的基质中,MMP-2、MMP-9及TIMP-1在胃癌中的表达程度与患者的年龄、肿瘤大小、病理分级无关，而与患者的淋巴结转移情况相关（P<0.05）。结论：MMP-2、MMP-9和TIMP-１与胃癌的临床病理特点和转移预后密切相关，可作为判定胃癌生物学行为和预后的重要指标。

Relationships between expressions of MMP-2, MMP-9, TIMP-1 in gastric carcinoma and pathological characteristics and prognosis

Objective To study the relationships of expressions of MMP-2,MMP-9,TIMP-1 in gastric carcinoma and pathological characteristics in clinic metastasis and prognosis.Methods Immunohistochemistry and morphologic quantitative analysis were used.Results Expression levels of MMP-2 and MMP-9 in gastric carcinoma matrix were markedly higher than those of pericarcinoma normal tissues(P<0.01).TIMP-1 expressed in(pericarcinoma) matrix.There were no any relationships between the expression levels of MMP-2,MMP-9,TIMP-1 in gastric carcinoma and patients′ age,tumor size,pathological grading,but there was obvious relationship between expression levels of MMP-2,MP-9,TIMP-1 and lymph node metastasis(P<0.05).Conclusion There are close relationships between the expressions of MMP-2,MMP-9,TIMP-1 in gastric carcinoma and pathological characteristics in clinic metastasis and prognosis.They may be used as important indexes to judge the biological behavior and prognosis of gastric carcinoma.