性激素替代治疗与乳腺癌

目前世界范围内乳腺癌发病率呈上升趋势Ｍａｒｉａｎｎｅ指出１９８５年时医学家估计全世界每年出现７２万新病例，预计至２０００年每年将出现１００万新病例［１］之所以出现乳癌发病率增长，其原因是与妇女平均寿命的提高有关，因为４０岁以上妇女乳腺癌的发生率升高...

Hormone Replacement Therapy and Breast Cancer

Estrogens in estrogen replacement therapy (ERT) and progestogens in hormone replacement therapy (HRT) are very effective drugs which exert are not only beneficial on short and long-term effects,but also benefits on prophylactic actions for bone loss and the cardiovascular diseases,and Alzheimer disease.However the risk of breast cancer is always discussed on the side effects of HRT. Estrogens are not considered as carcinogenic.As mitogens,estrogens may act as growth promoters,if malignant transformation has already occurred due to the influence of other factors.Progestogenis might decrease the risk of breast cancer.The risk of breast cancer starts increasing after five years or more of hormone replacement therapy,but without a further increasing after 10 years or more.HRT of combined oestrogen with progestogen users shows a clear trend to decrease, the mortality risk compared to the unusers.However woman slifetime risk of death due to coromary hart disease is 10 times greater than the risk of death from the cancer of breast.