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| 5-羟色胺转运蛋白基因多态性与精神分裂症的传递不平衡分析 | |
| 引用本文： | 孙伟伟,樊金波,钱学庆,唐君霞,行养玲,史建国,朱韶敏,刘会军,顾牛范,冯国鄞,贺林.5-羟色胺转运蛋白基因多态性与精神分裂症的传递不平衡分析[J].中华医学遗传学杂志,2003,20(4):342-344. |
| 作者姓名： | 孙伟伟 樊金波 钱学庆 唐君霞 行养玲 史建国 朱韶敏 刘会军 顾牛范 冯国鄞 贺林 |
| 作者单位： | 1. 200030,上海交通大学Bio-X生命研究中心 2. 中国科学院上海生命科学研究院 3. 西安精神卫生中心 4. 吉林省四平市精神卫生中心 5. 上海市精神卫生中心 |
| 基金项目： | 国家863计划项目(2001AA224011);973计划项目(G1998051002);上海市科委项目(99TC14047) |
| 摘 要： | 目的 探讨5—羟色胺转运蛋白基因第2内含子可变数目串联重复序列(Intronic，variable number tandem repeat，Intronic VNTR)位点和启动子区VNTR位点(5—HTTLPR)在精神分裂症发病机理中的作用。方法 应用传递不平衡分析方法对来自上海、西安和吉林的总计314个精神分裂症简单核心家庭进行分析。结果 三地单独及合并样本的传递不平衡分析结果表明，这两个多态位点由杂合子父母传递给患病子女的等位基因频率差异无显著性。结论 5—羟色胺转运蛋白基因上Intronic VNTR和5—HTTLPR多态位点在中国汉族人群精神分裂症发病机理中不起主要作用。 |
| 关 键 词： | 精神分裂症 5-羟色胺转运蛋白 基因多态性 传递不平衡检验 |
| 修稿时间： | 2002年8月20日 |
Transmission disequilibrium test of polymorphisms of serotonin transporter gene and schizophrenia based on family trios |
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| SUN Wei-wei,FAN Jin-bo,QIAN Xue-qing,TANG Jun-xia,XING Yang-lin,SHI Jian-guo,ZHU Shao-min,LIU Hui-jun,GU Niu-fan,FENG Guo-yin,HE Lin..Transmission disequilibrium test of polymorphisms of serotonin transporter gene and schizophrenia based on family trios[J].Chinese Journal of Medical Genetics,2003,20(4):342-344. | |
| Authors: | SUN Wei-wei FAN Jin-bo QIAN Xue-qing TANG Jun-xia XING Yang-lin SHI Jian-guo ZHU Shao-min LIU Hui-jun GU Niu-fan FENG Guo-yin HE Lin |
| Institution: | Bio-X Life Science Research Center, Shanghai Jiaotong University, Shanghai, 200030 PR China. |
| Abstract: | Objective To investigate the relationship between two polymorphisms (Intronic VNTR and 5-HTTLPR) of the serotonin transporter gene and schizophrenia. Methods A set of 314 schizophrenic trio samples collected from Shanghai, Xi'an and Jilin regions of China independently was subjected to analysis of the polymorphisms by transmission/disequilibrium test (TDT). Results No significantly preferential transmission of any allele was detected from both polymorphisms investigated. Conclusion The results suggest that the serotonin transporter gene is unlikely to have a major contribution to susceptibility to schizophrenia in Han Chinese population. |
| Keywords: | schizophrenia serotonin transporter gene variable number of tandem repeat transmission/disequilibrium test |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |