| 电刺激治疗对脑梗死大鼠运动功能和脑组织微管相关蛋白-2及存活素表达的影响 |
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| 引用本文： | 司志华,张秀清,唐吉友.电刺激治疗对脑梗死大鼠运动功能和脑组织微管相关蛋白-2及存活素表达的影响[J].临床神经病学杂志,2009,22(2). |
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| 作者姓名： | 司志华 张秀清 唐吉友 |
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| 作者单位： | 山东大学附属千佛山医院神经内科,济南,250014 |
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| 基金项目： | 山东省卫生厅计划课题(2007WH114) |
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| 摘 要： | 目的探讨电刺激对脑梗死大鼠运动功能和脑组织微管相关蛋白-2(MAP-2)及存活素表达的影响。方法采用线栓法制作大鼠局灶性脑梗死模型。制模后24h起,分别给予大鼠瘫痪侧(单侧)或双侧肢体电刺激治疗3d、7d、14d和21d。电刺激前、后各时间点用平衡木试验(BWT)检测大鼠的肢体运动功能,用免疫组化染色检测梗死灶周围大脑皮质MAP-2和存活素的表达水平,并与脑梗死对照组和假手术组大鼠比较。结果治疗第7d起电刺激组大鼠瘫痪肢体的BWT评分明显高于对照组(均P<0.05),治疗14d起双侧电刺激组BWT评分明显高于单侧电刺激组(均P<0.05)。治疗第7d起,电刺激组梗死灶周围脑组织MAP-2表达水平明显高于对照组(均P<0.05);治疗14d起,双侧电刺激组MAP-2的表达水平明显高于单侧电刺激组(均P<0.05);治疗21d时与假手术组MAP-2表达水平比较差异无统计学意义。电刺激组治疗后各时间点梗死灶周围脑组织存活素表达水平明显高于假手术组(均P<0.05),治疗7d、14d存活素表达水平明显高于对照组(均P<0.05),达到高峰;而双侧电刺激组明显高于单侧电刺激组(均P<0.05);治疗21d时,电刺激组和...
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| 关 键 词： | 脑梗死 电刺激治疗 微管相关蛋白 存活素 |
Effects of electric stimulation treatment on motor function and expression of microtubule-associated protein-2 and survivin of brain tissue in cerebral infarction rats |
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| SI Zhi-hua,ZHANG Xiu-qing,TANG Ji-you.Effects of electric stimulation treatment on motor function and expression of microtubule-associated protein-2 and survivin of brain tissue in cerebral infarction rats[J].Journal of Clinical Neurology,2009,22(2). |
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| Authors: | SI Zhi-hua ZHANG Xiu-qing TANG Ji-you |
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| Institution: | SI Zhi-hua,ZHANG Xiu-qing,TANG Ji-you.Department of Neurology,Qianfoshan Hospital Affiliated to Sh,ong University,Jinan 250014,China |
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| Abstract: | Objective To investigate the effects of electric stimulation on motor function and expression of microtubule-associated protein-2(MAP-2) and survivin of brain tissue in the cerebral infarction rats.Methods Cerebral infarction rat models were made using middle cerebral artery occlusion.After cerebral infarction for 24 h,the rats were respectively treated with electric stimulation on paralyzed(unilateral)or bilateral limbs for 3 d,7 d,14 d,21 d.By using beam walking test(BWT) and immunehistochemistry,the moto... |
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| Keywords: | cerebral infarction electric stimulation treatment microtubule-associated protein-2 survivin |
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