| 侧脑室注射生长抑素对大鼠痛阈和电针镇痛作用的影响 |
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| 引用本文： | 刘玲爱,宋朝佑.侧脑室注射生长抑素对大鼠痛阈和电针镇痛作用的影响[J].第二军医大学学报,1996,17(4):362-365. |
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| 作者姓名： | 刘玲爱 宋朝佑 |
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| 作者单位： | [1]中国人民解放军北京医学高等专科学校生理学教研室 [2]第二军医大学基础医学部神经生理学教 |
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| 摘 要： | 观察脑内生长抑素对痛阈和针刺镇痛的影响。以钾离子透入引起大鼠甩尾为测痛方法,侧脑室注射生长抑素,生长抑素的耗竭剂半胱胺和抗生长抑素血清,电针刺激大鼠足三里。侧脑室注射ＳＳ使大鼠痛阈升高并使电针镇痛的效应增强,侧脑室分别注射ＣＳＨ和ＡＳＳＳ使大鼠前阈降低并使电针镇痛的效应减弱。
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| 关 键 词： | 生长抑素 半胱胺 痛阈 电针镇痛 侧脑室 |
Effect of intracerebroventricular injection of somatostatin on pain threshold and electroacupuncture analgesia in the rat |
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| Liu Linai,Song Chaoyou,Wang Jingming,Yu Jing,Lin Baocheng.Effect of intracerebroventricular injection of somatostatin on pain threshold and electroacupuncture analgesia in the rat[J].Academic Journal of Second Military Medical University,1996,17(4):362-365. |
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| Authors: | Liu Linai Song Chaoyou Wang Jingming Yu Jing Lin Baocheng |
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| Abstract: | Objective:To investigate the effects of somatostatin(SS) on pain threshold and electroacupuncture analgesia(EA).Methods:The tail-flick induced by potassium iontophoresis was used to measure the change of pain threshold following intracerebroventricular(ICV) injection of SS,cysteamine(CSH) and anti-somatostatin serum(ASSS) and EA the "Zusanli".Results:The ICV injection of SS not only elevated the pain threshold,but also enhanced the EA analgesia, but CSH and ASSS decreased the PT and attenuated EA analgesia.Conclusion:Both exogenous and endogenous SS might be involved in modulation of pain and play an important role in EA analgesia. |
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| Keywords: | somatostatin cysteamine anti-somatostatin serum pain threshold electroacupuncture analgesia |
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