大肠癌术后5—Fu、醛氢叶酸、左旋咪唑联合化疗的临床研究

目的 评价大肠癌术后5－Fu、醛氢叶酸（CF）及左旋咪唑（LV）联合化疗的疗效。方法 242例大肠癌根治术后患者随机分成3组。Ⅰ组，80例，应用5－Fu CF化疗，Ⅱ组，80例，应用5－Fu LV化疗；Ⅲ组，82例，应用5－Fu CF LV化疗。结果 Ⅰ、Ⅱ、Ⅲ组肿瘤复发率分别为26．25％、27．50％和12．20％，Ⅲ组与Ⅰ、Ⅱ组比较差异有显著性意义（P＜0．05）；3组的5年生存率分别为37．5％、35．0％和58．5％，Ⅲ组与Ⅰ、Ⅱ组比较差异有显著性意义（P＜0．01），结论 5-Fu,CF,LV三联化疗能有效降低大肠癌术后复发率，提高生存率，是大肠癌术后辅助化疗较好的方案。

CLINICAL STUDY ON THEALLIED CHEMOTHERAPY WITH 5-Fu

Objective　To evaluate the effect of the allied chemotherapy with 5-Fu、leucovorin (CF) and levamisole (LV) after resection of colorectal cancer. Methods　242 cases were divided randomly into three groups. 80 cases (group Ⅰ) were treated with 5-Fu and CF. 80 cases(groupⅡ) were treated with 5-Fu and LV. 82 cases (group Ⅲ) were treated with 5-Fu、CF and LV. Results　The recurrence rates of group Ⅲ was 12.20%, which was significantly lower than that of group Ⅰ (26.25%) and group Ⅱ(27.50%). (P＜0.05). The 5-year survival rates in group Ⅰ, group Ⅱ and group Ⅲ were 37.50%, 35.00% and 58.54%, respectively, the highest one was in Group Ⅲ (P＜0.01). Conclusion　The allied chemotherapy with 5-Fu、CF and LV is an effective therapy for petients of colorectal cancer after surgery, which can significantly decrease the recurrence and improve the 5-year survival rate.