溶组织内阿米巴与日本血吸虫并存感染实验观察

选用长爪沙鼠,分别经皮肤感染20条日本血吸虫尾蚴和盲肠内接种溶组织内阿米巴滋养体5×10~5个/0.5ml,建立溶组织内阿米巴与日本血吸虫并存感染的实验动物模型。结果表明,血吸虫感染可以促进肠阿米巴病的发生与发展,并使潜在的溶组织内阿米巴感染发展成侵入型肠阿米巴病。并存感染既有阿米巴感染和血吸虫感染的部分病理学特征,又有本身独特的病理学变化,机体的应激反应参与致病过程。病灶区经常可见滋养体与虫卵的粘附,两者之间似存在亲和性。

EXPERIMENTAL STUDIES ON THE CONCURRENT INFECTIONS WITH ENTAMOEBA HISTOLYTICA AND SCHISTOSOMA JAPONICUM

The mongolian gerbil (Merious unguiculatus) was used as an experimental animal model for studying the concurrent infections and pathogenicities with Entamoeba histolytica (E. h.) and Schistosoma japonicum (S. j.) by the cutaneous infection with 20 fresh cercariae of S. j. and the intracaecal inoculation of 5 x 10(5)/0.5 ml amebic suspension. Light and electron microscopy were used to observe the pathological changes of the caecal wall in the concurrent infections. The results showed that S. j. infection could promote the development of caecal amoebiasis, and stimulate symbiotic E. h. infection to develop invasive caecal amoebiasis. The pathological characteristics of the concurrent two infections not only exhibited the characteristics of the single E. h. or S. j. infection, but also showed its own specialty. Immunological effect of the host was apparently involved in the pathogenic process. In addition, the trophozoites of E. h. were usually observed to adhere closely to the egg shell of S. j. at the site of tissues necrosis. From the adherence phenomenon observed in our studies, there might exist an affinity mechanism between the E. h. trophozoite and S. j. ovum.