自制复方中药提取物对动物心肌梗死及耐缺氧的作用研究

目的 研究自制复方中药提取物对心肌梗死及耐缺氧的作用.方法 以小鼠、家兔为试验对象,给以银杏叶、人参、川芎、五味子提取物自制的复方中药,检测其对小鼠常压耐氧时间的影响,以及对家兔冠状动脉结扎致心肌梗死的影响.结果 常压耐缺氧条件下,以银杏叶、人参、川芎、五味子提取物制成的中成药能明显延长小鼠耐缺氧时间,并对家兔冠状动脉结扎所致心肌缺血有明显保护作用,使心肌梗死程度减轻,抑制急性心肌缺血所致ST段抬高.结论 该复方中药提取物能明显改善动物的心肌梗死及机体耐氧能力.

Effect of Self-Made Compound Extract of Chinese Medicine on Myocardial Infarction and Bearing Hypoxia

Objective To study the effect of self-made compound extract of Chinese medicine on myocardial infarction and bearing hypoxia.Methods Rabbits and mice were taken as the experimental subjects and given the self-made compound Chinese medicine made by the extract of Ginkgo biloba,Panax ginseng,Ligustioum chuanxiong and Schisandra chinensls,its influence on the mice bearing hypoxia time under ordinary pressure atmospheric oxygen time and rabbits myocardial infarction caused by coronary ligation.Results On the condition of bearing hypoxia under ordinary pressure,the Chinese patent medicine prepared by the extracts from Ginkgo biloba,Panax ginseng,Ligustioum chuanxiong and Schisandra chinensls could significantly prolong the mice bearing hypoxia time,have obvious protective effects on the rabbit myocardial ischemia caused by coronary ligation,reduce the degree of myocardial infarction and inhibit ST-elevation caused acute myocardial ischemia.Conclusion This compound extract of Chinese medicine can obviously improve the ability of bearing hypoxia in myocardial infarction.