HBV-M阳性前S1蛋白临床上检测分析

目的:检测HBsAg前S1蛋白,评价其在病毒感染、复制、传染及对肝细胞损伤等方面的临床意义.方法:根据血清标志物(HBV-M),将298例HBsAg感染患者分为4组,即HBsAg(+)组(A组),HBsAg(+)-HBeAg(+)-HBcAg(+)组(B组),HBsAg(+)-HBcAb(+)-HBeAb(+)组(C组...

Clinical value of detection of Pre-S1 protein of hepatitis B virus

Objective： To evaluate the clinical value of Pro-S1 protein in detection of HBV replication,infectivity and liver cell injury.Methods： A total of 298 cases with positive HBsAg were divided into 4 groups according to serum index（HBV-M）： HBsAg（＋） Group（Group A）,HBsAg（＋）-HBeAg（＋）-HBcAg（＋） Group（Group B）,HBsAg（＋）-HBcAb（＋）-HBeAg（＋）（Group C）,and HBeAg（＋）-HBcAg（＋）（Group D）.Pre-S1 protein,HBV-DNA and ALT of each group were determined and analyzed.Results：Among 298 cases,140 cases were positive in Pre-S1 protein test（46.98%）,including 12 cases in Group A,50 in Group B,60 in Group C and 18 in Group D;119 cases were positive in HBV-DNA test（39.93%）,including 4 cases in Group A,42 in Group B,51 in Group C and 22 in Group D;124 cases showed abnormal results of ALT level（41.61%）,including 3 cases in Group A,45 in Group B,55 in Group C and 21 in Group D.There were no significant difference in the positive rates of pre-S1 protein and HBV-DNA（P0.05）.The correlation coefficient was 0.98.The χ2 test showed no significant difference（P0.01）.Conclusions： If the result of Pre-S1 protein detection is positive,no matter the results of HBeAg and ALT are normal or abnormal,HBV has the capability of replication and infection.Pre-S1 protein could be regarded as a criterion of infection,replication,infectivity and liver cell injury of HBV.