Snail mRNA与环氧化酶-2mRNA在乳腺癌中的表达及临床意义

目的 探讨Snail mRNA及环氧化酶-2(COX-2) mRNA在乳腺浸润性导管癌中的表达及其临床意义.方法 应用原位杂交技术测定30例乳腺单纯性增生、30例乳腺导管内癌和70例乳腺浸润性导管癌组织中Snail mRNA及COX-2 mRNA的表达.结果 ①Snail mRNA及COX-2 mRNA在乳腺单纯性增生...

The Expression and Clinical Significance of Snail mRNA and COX-2 mRNA in Breast Cancer

Objective To investigate the expressions of Snail mRNA and COX-2 mRNA in invasive ductal carcinoma and their clinical significance.Methods The expressions of Snail mRNA and COX-2 mRNA were detected on mammary gland hyperplasia（30 cases）,intraductal breast carcinoma（30 cases） and invasive ductal carcinoma（70 cases） by in situ hybridization.Results ①The positive expression rates of Snail mRNA and COX-2 mRNA in mammary gland hyperplasia,intraductal breast carcinoma and invasive ductal carcinoma respectively were 23.3%,46.7%,81.4% and 13.3%,63.3%,77.2%,and there were significant differences among them（P0.01）.But there were no differences between Snail mRNA and COX-2 mRNA in the same group（P0.05）.②Snail mRNA and COX-2 mRNA expressions were related to lymphatic metatasis（P0.05,P0.01）,but were not related to age,tumor size and histopathological grade（P0.05）.③There was a positive correlation between Snail mRNA and COX-2 mRNA in invasive ductal carcinoma tissues（r=0.53,P0.01）.Conclusion Snail mRNA and COX-2 mRNA may play an important role in the origin and development of breast carcinoma,and their expressions are of important diagnostic value in breast cancer prognosis.