| 宫腔注射无水乙醇对小鼠动情周期的影响 |
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| 引用本文： | 张引红,王春芳,郭民,张锐虎,陈朝阳.宫腔注射无水乙醇对小鼠动情周期的影响[J].中国比较医学杂志,2017,27(5):51-54. |
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| 作者姓名： | 张引红 王春芳 郭民 张锐虎 陈朝阳 |
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| 作者单位： | 山西医科大学实验动物中心, 实验动物与人类疾病动物模型山西省重点实验室, 太原 030001,山西医科大学实验动物中心, 实验动物与人类疾病动物模型山西省重点实验室, 太原 030001,山西医科大学实验动物中心, 实验动物与人类疾病动物模型山西省重点实验室, 太原 030001,山西医科大学实验动物中心, 实验动物与人类疾病动物模型山西省重点实验室, 太原 030001,山西医科大学实验动物中心, 实验动物与人类疾病动物模型山西省重点实验室, 太原 030001 |
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| 基金项目： | 山西省实验动物资源共享服务平台建设（201605D121019）；山西省重点实验室建设项目（2015012001-09）。 |
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| 摘 要： | 目的探讨宫腔内注射无水乙醇对小鼠动情周期的影响。方法利用阴道脱落细胞染色法选择动情期规律的小鼠20只,宫腔注射无水乙醇,术后第一个动情周期内每日测定其动情周期,随机择10只在第二个动情周期每2 h测一次,观察动情周期的改变程度。结果实验小鼠宫腔注射无水乙醇后动情周期整体发生大幅度延长,且动情期、动情前期等各期时间均发生了不同程度的紊乱。结论本实验通过观测无水乙醇损伤子宫后小鼠动情周期发生紊乱的现象,为临床无水乙醇的使用提供一定的实验基础。
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| 关 键 词： | 无水乙醇 宫腔注射 动情周期 |
| 收稿时间： | 2017/1/20 0:00:00 |
| 修稿时间： | 2017/3/23 0:00:00 |
Effects of intrauterine injection of ethanol on estrous cycle in mice |
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| ZHANG Yin-Hong,WANG Chun-fang,GUO Min,ZHANG Rui-hu and CHEN Zhao-yang.Effects of intrauterine injection of ethanol on estrous cycle in mice[J].Chinese Journal of Comparative Medicine,2017,27(5):51-54. |
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| Authors: | ZHANG Yin-Hong WANG Chun-fang GUO Min ZHANG Rui-hu and CHEN Zhao-yang |
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| Institution: | Department of Laboratory Animal Science, Shanxi Key Laboratory of Laboratory Animal and Animal Model of Human Diseases, Shanxi Medical University, Taiyuan 030001, China,Department of Laboratory Animal Science, Shanxi Key Laboratory of Laboratory Animal and Animal Model of Human Diseases, Shanxi Medical University, Taiyuan 030001, China,Department of Laboratory Animal Science, Shanxi Key Laboratory of Laboratory Animal and Animal Model of Human Diseases, Shanxi Medical University, Taiyuan 030001, China,Department of Laboratory Animal Science, Shanxi Key Laboratory of Laboratory Animal and Animal Model of Human Diseases, Shanxi Medical University, Taiyuan 030001, China and Department of Laboratory Animal Science, Shanxi Key Laboratory of Laboratory Animal and Animal Model of Human Diseases, Shanxi Medical University, Taiyuan 030001, China |
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| Abstract: | Objective To investigate the effect of uterine cavity injection of absolute ethanol on estrous cycle in mice.Methods Twenty mice with regular estrous cycle were selected by vaginal exfoliated cells staining, and then were injected absolute ethanol into their uterine cavity. The estrous cycle was observed and recorded every day. Ten mice were selected randomly to observe the changes of second estrous cycle every two hours.Results After the injection of absolute ethanol into the uterine cavity of the experimental mice, the estrous cycle was greatly prolonged, and the various degree of disorder was observed in estrus and pre-estrus. Conclusions The disorder was observed in estrous cycle of mice after the injection of absolute ethanol, which maybe provides some references for clinical use of absolute ethanol. |
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| Keywords: | Ethanol Intrauterine injection Estrous cycle |
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