磷脂酶A2和ERK2与乳腺癌发生发展的关系

目的磷脂酶A2（CPLA2）作为活化的细胞外信号调节激酶（P—ERK2）的底物，与乳腺癌发生发展具有密切关系。本研究旨在阐明CPLA2、ERK2在乳腺癌发生发展中的作用及其相互之间存在的关系。方法应用免疫组织化学二步法，分别检测48例乳腺癌、21例乳腺纤维腺瘤和21例乳腺腺病组织中CPLA2和ERK2的表达水平。结果乳腺癌组织中CPLA2和ERK2的表达明显高于乳腺纤维腺瘤和乳腺腺病组织，且乳腺癌组织中CPLA2和ERK2的表达与TNM分期呈正相关，CPLA2与乳腺癌组织肿瘤直径、术后生存时间、淋巴结转移个数均成正相关，且CPLA2和ERK2之间呈显著正相关关系。结论ERK2可以通过促进CPLA2的表达促进乳腺癌的发生发展。

Study on the expressions of cytosolic phospholipase A2 and extracellular signal-regulated kinase2 in breast carcinoma and their significance

Objective To investigate the relationship of the expressions of protein ePLA2 and ERK2 in the occurrence,development and prognosis of breast carcinoma. Methods The expressions of protein cPLA2 and ERK2 in 48 breast cancer cases ,21 breast adenosis tissue cases and 21 breast fibroadenoma cases by SP immunohistochemical method. Results The expression of cPLA2 in breast cancer tissue is apparently higher than that in breast adenosis tissue and breast fibroadenoma, and the differences are remarkably significant（ P 〈 0.05 ）. After statistical analysis,it is found that the cPLA2 expression has positive relationship with TNM stage（ P 〈 0.05 ） ;The expression of cPLA2 protein levels increased remarkably in lymph node metastasis groups in comparison to no lymph node metastasis groups, and the differences are remarkably significant（ P 〈 0.05 ） ;The greater the diameter of the tumor ,the higher the positive rate of cPLA2 expression, and the differences are remarkably significant（ P 〈 0.05 ） ;Conclusion ERK2 promote the occurrence and development of breast cancer by increasing the cPLA2 expression.