宫内人巨细胞病毒感染的前瞻性研究

应用ＥＬＩＳＡ方法及聚合酶链反应，对１８１８例孕母及其婴儿进行孕期人巨细胞病毒感染的母婴间宫内传播的前瞻性研究。结果表明：孕母ＨＣＭＶ－ＩｇＧ阳性率为８９．２％；孕母ＨＣＭＶ活动性感染率为４．５％，孕早、中、晚各期ＨＣＭＶ活动性感染率分别为２．４％、３．５％、１．９％，其中原发感染略高于１．１％，提示孕期大多数孕妇为复发感染；孕母ＨＣＭＶ抗体在孕期有阳转或阴转的不同变化；孕母不仅ＨＣＭＶ－ＩｇＭ阳

A PROSEPECTIVE STUDY OF THE INFLUENCE OF THE CONGENITAL HCMV INFECTION ON THE QUALITY OF FETUS AND NEONATES

818 pregnant women and their infants in Yang-pu District Shanghai were studied withthe ELISA and PCR techniques prospectively to determine the state of congenital HCMV in-fection. The results indicated that the maternal HCMV-IgG seropositive rate was 89.2%,whereas the maternnal active infection rate was 4.5% with that of 2.4%,3.5%,1.9%forthe three trimesters respectively. The primary maternal infections accounted for only 1.1%,which indicated that the majority maternal infections were recurrent infections. The maternalHC MV-IgG antibodies underwent a variable seroconversion during pregnancy which showed20.5%positive-conversion rate and 1.0 %negative-conversion rate,The presence of maternal HCMV-IgG antibodies did not prevent the transmission of HCMV from mother to the fe-tus,We concluded that the diagnosis of the congenital HCMV infection using the ELISA andthe PCR techniques played a significant role in the early intervention and the consequent im-proving of the disease. Long term follow up of those infected infants was necessary.