心肌营养素-1与左心室收缩功能障碍关系的临床分析

目的探讨心肌营养素-1（CT-1）与左心室收缩功能障碍（LVSD）的关系。方法选择LVSD患者33例为LVSD组，非LVSD患者30例为对照组，测量2组身高、体重和血浆CT-1。应用彩色多普勒超声测量并计算短轴缩短率（FS）、左心室射血分数（EF）和左心室质量指数（MI）。结果LVSD组的血浆CT-1水平和MI较对照组高，FS较对照组低，均有统计学意义。LVSD组的血浆CT-1水平的对数与FS的对数呈负相关（r=-0．68，P〈0．01），与MI的对数呈正相关（r=0．63，P〈0．05），与EF的对数呈负相关（r=-0．70，P〈0．01）。结论血浆CT-1与LVSD有关，其浓度水平与收缩性心力衰竭严重程度有关。

Correlation between plasma cardiotrophin-1 and left ventricular systolic dysfunction

Objective To observe the Correlation between plasma cardiotrophin-1 （CT-1） and left ventricular systolic dysfunction （LVSD）. Methods Thirty-three LVSD cases were included, with 30 non-LVSD cases as a control group. Height, weight and the concentration of plasma CT - 1 of the two groups were analyzed. Meanwhile, the Fractional Shortening （FS）, the Ejection Fraction （EF） and the Mass Index （MI） by echocardiography were also recorded. Results Plasma level of CT-1 and MI were significantly higher in LVSD patients than that in control group（ P 〈 0.01 ,P 〈 0.05 ）. The FS of LVSD patients were lower than that of non-LVSD patients （P 〈0.01 ）. Meanwhile, in LVSD group, log plasma CT-1 level showed negative correlations with log FS and log EF（r= -0. 68 and 0.70,P 〈0.01）, with a positive correlation with log MI （r=0. 63,P 〈0.05）. Conclusion The level of plasma CT-1 was correlated to the severity of LVSD.