院内鲍曼不动杆菌耐药性分析

目的：了解院内感染鲍曼不动杆菌对临床常用抗菌药物的耐药性及分布情况，为临床合理使用抗菌药物提供依据。方法对2011年1月至2012年10月本院临床分离的125株鲍曼不动杆菌对亚胺培南等14种抗菌药物的耐药性及分布进行回顾性分析。结果125株鲍曼不动杆菌对复方新诺明、哌拉西林、头孢噻肟、庆大霉素、头孢吡肟、替卡西林/克拉维酸、环丙沙星、头孢他啶、哌拉西林/他唑巴坦、阿米卡星、左氧氟沙星、妥布霉素、氨苄西林/舒巴坦和亚胺培南的耐药率依次为82.4%（103/125）、75.2%（94/125）、75.2%（94/125）、74.4%（93/125）、74.4%（93/125）、73.6%（92/125）、72.8%（91/125）、72.0%（90/125）、75.2%（94/125）、70.4%（88/125）、69.6%（87/125）、69.6%（87/125）、67.2%（84/125）和66.4%（83/125）。所分离的125株菌中，117株来源于痰液，60株来源于重症监护病房，14株来源于神经外科。结论院内鲍曼不动杆菌主要导致呼吸道感染，对临床常用抗菌药物的耐药率很高，临床中应根据药敏试验结果合理选用抗菌药物。

Resistance analysis and distribution of Acinetobacter baumannii

Objective To investigate the resistance of nosocomial acinetobacter baumannii to clinical commonly used antimicrobial drugs and it’s distribution, and for clinical rational use of antimicrobial agents. Methods Total of 125 strains of acinetobacter baumannii were separated in our hospital 2012. The resistance of those strains to 14 kinds of antibacterial drugs and the distribution were analyzed, retrospectively. Results The resistance rates of 125 strains of acinetobacter baumannii to compound SMZ, piperacillin, cefotaxime, gentamycin, cefepime, ticarcillin/clavulanic acid, cipro, ceftazidime, piperacillin/tazobactam sodium, jotham, amikacin, levofloxacin, tobramycin, ampicillin/sulbactam and imipenem were 82.4% （103/125）, 75.2% （94/125）, 75.2% （94/125）, 74.4% （93/125）, 74.4% （93/125）, 73.6% （92/125）, 72.8%（91/125）, 72.0% （90/125）, 75.2% （94/125）, 70.4% （88/125）, 69.6% （87/125）, 69.6% （87/125）, 67.2% （84/125） and 66.4% （83/125）, respectively. There were 117 strains specimens were from sputum; 60 strains were from intensive care unit （ICU） and 14 strains specimens were from the department of neurosurgery. Conclusions The resistance rate of acinetobacter baumannii to clinical commonly used antimicrobial drugs was very high. It mainly causes respiratory tract infection, clinical doctors should use rational antimicrobial agents based on the results of drug sensitivity.