| 克拉霉素缓释片释放度研究 |
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| 引用本文： | 吴闯,肖学成. 克拉霉素缓释片释放度研究[J]. 中国药房, 2004, 15(4): 238-239 |
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| 作者姓名： | 吴闯 肖学成 |
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| 作者单位： | 1. 广西医科大学附属第一医院,南宁市,530027
2. 湖北省药检专科学校,武汉市,430064 |
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| 摘 要： | 目的:研究自制克拉霉素缓释片的体外释放度。方法:以紫外分光光度法测定自制克拉霉素体外释放度。结果:释放度曲线经Weibull分布拟合,自制缓释片为lnln 1/(1-F(t))=1.5 291 lnt-3.7 539(r=0.9 842);进口缓释片为lnln 1/(1-F(t))=1.5 216 lnt-3.6 759(r=0.9 830)。自制和进口克拉霉素缓释片的释放度基本一致。结论:自制克拉霉素缓释片有较好的释药性能。本文建立的释放度测定方法可作为该制剂的质控方法。
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| 关 键 词： | 克拉霉素 缓释片 释放度 |
| 文章编号： | 1001-0408(2004)04-0238-02 |
| 修稿时间： | 2003-12-04 |
Study on the Dissolubility of Clarithromycin Slow-released Tablet |
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| WU Chuang. Study on the Dissolubility of Clarithromycin Slow-released Tablet[J]. China Pharmacy, 2004, 15(4): 238-239 |
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| Authors: | WU Chuang |
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| Abstract: | OBJECTIVE: To study the dissolution rate of clarithromycin slow - released tablet in vitro. METHODS: The dissolubility of clarithromycin slow- released tablet was determined by UV - spectrophotometry .RESULTS: The Weibulls distribution function equation of self - prepared and imported clarithromycin slow - released tablets were lnln1/1-F(t)=1.5 291 lnt-3.7 539, (r = 0.9 842) and lnln1/1-F(t)=1.5 216 lnt-3.6 759,(r = 0.9 830) .respectively .The dissolution rates of self-prepared and imported slow - released tablets were comparable.CONCLUSION: The study indicates that the self - prepared slow - released tablet had satisfactory sustained release effect.The method established for assaying the dissolution rate was suitable for quality control of clarithromycin slow - released tablet. |
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| Keywords: | clarithromycin slow-released tablet dissolubility |
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