| TMB—8抑制组胺,5—羟色胺和谷氨酸引起的培养乳牛基底动脉平滑肌细 … |
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| 引用本文： | 王斌 张孝清. TMB—8抑制组胺,5—羟色胺和谷氨酸引起的培养乳牛基底动脉平滑肌细 …[J]. 中国药理学报, 1998, 19(3): 251-253 |
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| 作者姓名： | 王斌 张孝清 |
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| 摘 要： |
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| 关 键 词： | TMB－8 钙 脑血管平滑肌 组胺 5－羟色胺 谷氨酸钠 |
8-(N,N-diethylamino)-n-octyl-3,4,5-trimethoxybenzoate reduced [Ca2+]i elevation induced by histamine, serotonin, and glutamate in cultured calf basilar artery smooth muscle cells. |
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| B Wang,X Q Zhang,T P Liu,J G Xiao. 8-(N,N-diethylamino)-n-octyl-3,4,5-trimethoxybenzoate reduced [Ca2+]i elevation induced by histamine, serotonin, and glutamate in cultured calf basilar artery smooth muscle cells.[J]. Acta Pharmacologica Sinica, 1998, 19(3): 251-253 |
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| Authors: | B Wang X Q Zhang T P Liu J G Xiao |
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| Affiliation: | Department of Pharmacology, Nanjing Medical University, China. qj73@hotmail.com |
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| Abstract: | AIM: To study the effects of 8-(N,N-diethylamino)-n-octyl-3,4,5- trimethoxybenzoate (TMB-8) on intracellular free calcium ([Ca2+]i) in cultured calf basilar artery smooth muscle cells. METHODS: [Ca2+]i was examined by a system of measurement of AR-CM-MIC, using Fura 2-AM as a fluorescent indicator. RESULTS: In the presence of extracellular Ca2+ 1.3 mmol.L-1, histamine (His), serotonin (5-HT), and sodium glutamate (Glu) markedly increased the [Ca2+]i which was attenuated by TMB-8. In Ca2+ free Hanks' solution containing egtazic acid 0.1 mmol.L-1, TMB-8 not only reduced the resting [Ca2+]i, but also inhibited the elevation of [Ca2+]i evoked by His and 5-HT. CONCLUSION: TMB-8 reduced the resting [Ca2+]i and attenuated His-, 5-HT-, and Glu-induced increases of [Ca2+]i in basilar artery smooth muscle cells. |
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