| 正交试验优选治伤灵颗粒剂的水提醇沉工艺 |
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| 引用本文： | 张世波,曹清远. 正交试验优选治伤灵颗粒剂的水提醇沉工艺[J]. 中国医药指南, 2012, 10(6): 47-49 |
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| 作者姓名： | 张世波 曹清远 |
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| 作者单位： | 1. 泸州市中医院,四川泸州,646000
2. 四川泸州食品药品检验所,四川泸州,64600 |
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| 摘 要： | 目的优选治伤灵颗粒剂的水提醇沉工艺。方法以芍药苷含量和干膏率为指标,应用正交设计试验,采用多指标综合评分法进行数据分析,优化提取纯化条件。结果优选的提取纯化工艺为加8倍量水,煎煮2次,每次1 h,醇沉浓度70%。结论优选的工艺稳定、可行,适合医院制剂的批量生产。
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| 关 键 词： | 治伤灵颗粒剂 正交设计实验 水提醇沉工艺 |
Optimization of the Water Extracting and Alcohol Precipitating Technique of Zhisahngling Granule by Orthogonal Experiments |
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| ZHANG Shi-bo , CAO Qing-yuan. Optimization of the Water Extracting and Alcohol Precipitating Technique of Zhisahngling Granule by Orthogonal Experiments[J]. Guide of China Medicine, 2012, 10(6): 47-49 |
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| Authors: | ZHANG Shi-bo CAO Qing-yuan |
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| Affiliation: | 1 Luzhou Traditional Chinese Medicine Hospital, Luzhou 646000, China,＂ 2 Luzhou Institute for Foot and Drug Control, Luzhou 646000, China) |
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| Abstract: | Objective To optimize the water extracting and alcohol precipitating technology of Zhishangling granule. Methods With the yield of dry paste composition and paeoniflorin were used as index. An orthogonal test was adopted in the study. Data processing was carried out with the multiple guidelines grading method for optimizing the extraction and precipitation condition. Results The optimized extraction and precipitation technology for Zhishangling granule was shown to be using 8 times the volume of water, decocting for two times, 1 h in each time, and using 70% alcohol. Conclusion The optimized technology is rational and efficient. It＇s calculated for the Large-scale production of hospital. |
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| Keywords: | Zhishangling granule Orthogonal experiments The water extracting and alcohol precipitating technology |
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