依那普利联合吲达帕胺对糖尿病合并高血压患者血压晨峰现象的影响

目的：探讨依那普利联合吲达帕胺对糖尿病合并高血压患者血压晨峰现象的影响。方法将糖尿病合并高血压患者150例分成观察组和对照组，各75例。对照组给予依那普利治疗，观察组给予依那普利联合吲达帕胺治疗。结果治疗2、4、8周后，两组的舒张压、收缩压水平较治疗前降低，观察组的舒张压、收缩压水平低于对照组，差异有统计学意义（P〈0.01）。观察组血压晨峰控制有效率为92.00%，高于对照组的62.67%，差异有统计学意义（P〈0.01）。治疗后，两组的ET-1水平较治疗前降低，观察组的ET-1水平降低更明显，差异有统计学意义（P〈0.01）。结论采用依那普利联合吲达帕胺治疗糖尿病合并高血压的效果确切，能有效降低患者的血压，提高血压晨峰现象控制有效率。

Impact of enalapril combined with indapamide on morning blood pres-sure surge in diabetic patients with hypertension

Objective To study the effect of enalapril combined with indapamide on morning blood pressure surge in diabetic patients with hypertension. Methods 150 diabetic patients with hypertension were divided into observation group and control group,75 cases in each group.Enalapril treatment was used in control group,enalapril combined with indapamide treatment were applied in observation group. Results After treatment for 2,4,8 weeks,diastolic blood pressure,systolic blood pressure in two groups was lower than that before treatment respectively,diastolic blood pressure, systolic blood pressure in observation group was lower than that in control group respectively,with statistical difference （P〈0.01）.Morning blood pressure surge control effective rate in observation group was 92.00%,higher than that in control group （62.67%）,with statistical difference （P〈0.01）.After treatment,plasma-1 level in two groups was lower than that before treatment respectively,ET-1 level in observation group significantly decreased,with statistical difference （P〈0.01）. Conclusion Enalapril combined with indapamide in the treatment of diabetes complicated with hypertension has good effect,can effectively reduce the blood pressure,improve the morning blood pressure surge control effective rate.