重度子痫前期合并HELLP综合征母婴妊娠结局的分析

目的：探讨重度子痫前期合并HELLP综合征对母婴妊娠结局的影响。方法回顾性分析重度子痫前期并发HELLP综合征65例患者的临床资料，比较完全性组（30例）和部分性组（35例）患者的实验室数据和母婴妊娠结局。结果完全性组血小板计数低于部分性组，AST、ALT、乳酸脱氢酶和总胆红素均高于部分性组，差异有统计学意义（P〈0.05）；完全性组孕产妇胎盘早剥、急性心力衰竭、肺水肿、脑水肿、产后出血发生率高于部分性组，差异有统计学意义（P〈0.05）；完全性组胎儿生长受限、新生儿窒息发生率高于部分性组，差异有统计学意义（P〈0.05）；两组均无孕产妇死亡发生，围生儿死亡率比较差异无统计学意义（P〉0.05）。结论对于重度子痫前期并发HELLP综合征患者应及时诊断并治疗，可改善母婴妊娠结局。

Analysis of maternal-infant outcome in severe preeclampsia combined with HELLP syndrome

Objective To analyze impact of severe preeclampsia combined with HELLP syndrome on maternal-infant outcome. Methods The data of 65 patients with severe preeclampsia combined with HELLP syndrome were analysed retrospectively including 30 cases of complete HELLP syndrome and 35 partial HELLP syndrome.The blood test and maternal-infant outcome in complete group and partial group was analyzed respectively. Results PLT in complete group was lower than that in partial group,while AST,ALT,LDH and TBiL in complete group was higher than that in partial group respectively,with statistical difference （P〈0.05）.The incidence rate of placental abruption,heart failure,pulmonary edema,encephaledema,postpartum hemorrhage in complete group was higher than that in partial group respectively,with statistical difference（P〈0.05）.The incidence of FGR,neonatal asphyxia in complete group was higher than that in partial group respectively,with statistical difference （P〈0.05）.Between two groups,there was no maternal death and there was no statistical difference in perinatal death rate（P〉0.05）. Conclusion Timely diagnosis and treatment of severe preeclampsia combined with HELLP syndrome can improve the maternal-infant outcome.