Immunohistochemical Evaluation of 95 Bone Marrow Reactive Plasmacytoses |
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Authors: | Maria G. Ioannou Efstathios Stathakis Andreas C. Lazaris Thomas Papathomas Evangelos Tsiambas George K. Koukoulis |
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Affiliation: | (1) Department of Pathology, Medical School, University of Thessaly, Larisa, Greece;(2) Present address: 12 Kerkiras Str. (Kalamaria), Thessaloniki, 55133, Greece |
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Abstract: | We histologically and immunohistochemically studied 95 bone marrow (BM) reactive plasmacytoses. Ten biopsies from plasma cell myeloma (PCM) patients served as a control group. In addition, we studied 10 monoclonal gammopathy of undetermined significance (MGUS) cases. Histologically, plasmacytosis varied between 5% and 25% with an interstitial pattern of plasma cell (PC) distribution being characteristically displayed. Immunohistochemically, we did not find any CD56/NCAM nor cyclin D1 expression in all biopsies (95 of 95, 100%), not even a weak, doubtful one; PCs were all polyclonal and CD138 positive. On the contrary, myeloma-associated PCs showed monoclonality for κ- or λ- light chain and strong CD56/NCAM immunoreactivity (8 of 10, 80%); four of them were cyclin D1 positive. Osteoblasts exhibited similar CD56/NCAM expression in both groups. Our data confirm the diagnostic utility of CD56/NCAM in the phenotypic characterization of polyclonal plasma cells, suggesting an important role of this particular immunomarker in the BM trephine study of polyclonal versus neoplastic plasmacytic infiltrations. |
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Keywords: | CD56 Cyclin D1 Immunohistology Bone marrow biopsies Reactive plasmacytosis Plasma cell myeloma |
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