SSF对小鼠学习记忆的影响

目的：研究SSF对小鼠学习、记忆的作用。方法：采用水迷宫行为实验法，观察50、100、200mg／kg(灌胃，12d)的SSF对正常小鼠学习、记忆以及NaNO2引起小鼠记忆巩固、障碍的影响，脑复康作为对照药。结果：与盐水对照组小鼠相比，100、200mg／kg(灌胃，12d)的SSF、能够显著缩短正常小鼠到达终点平台的潜伏期和减少进入盲端的次数。脑复康对正常小鼠学习、记忆无显著作用。腹腔注射NaNO2120mg／kg显著增加小鼠到达终点的潜伏期和进入盲端的次数，50、100、200mg／kg的SSF和脑复康(200mg／kg)皆能够改善NaNO2引起小鼠记忆巩固障碍。结论：SSF具有增强小鼠学习记忆、改善NaNO2引起小鼠记忆巩固障碍的作用。

THE EFFECTS OF SSF ON LEARNING AND MEMORY IN MICE

Objective:To study of SSF on learning and memory in mice. Methods:The mice water maze performance was used to evaluate the effects of SSF on learning and memory and memory impairment of consolidation induced by NaNO 2 in mice. Piracetam (PIR) was used as reference drug. Results: During 5d acquisition trails, compared with saline control, SSF (100, 200mg/kg, ig, 12d) could significantly reduce the escape latency to find platform and the number errors entering non exit. No marked impact was found administration of PIR at dose of 200mg/kg in mice. NaNO 2 (120mg/kg, ip) consistently result in an increase the escape latency to find platform and the number errors entering non exit as compared with saline treated control. All the PIR (200mg/kg, ig,) and SSF (50, 100 and 200mg/kg, ig) could significantly lessen the increased latency and number errors. Conclusion : SSF could enhance learning and memory and ameliorate the impaired memory of consolidation induced by NaNO 2 in mice.