肾移植患者环孢素A血药浓度与胱抑素C的相关性分析

目的:研究肾移植患者术后不同时期的环孢素A(CsA)血药浓度与血清胱抑素C(CysC)和血清肌酐(Scr)的相关性。方法:118例肾移植患者术后肾功能稳定(肌酐清除率>40 ml/min),其中男性60例,女性58例,共监测307例次。术后同时监测CsA血药浓度、CysC值和Scr。结果:随着术后时间的延长,CsA血药浓度呈逐渐下降趋势,CysC的均值高于正常参考范围,而Scr值均在正常参考范围内。术后不同时间段组、不同药物浓度组的CsA血药浓度与CysC和Scr均无显著相关性。结论:肾移植术后CsA血药浓度的高低,不影响CysC、Scr对移植肾功能的评价。

Analysis of the Correlation between Blood Concentration of Cyclosporine A and Cystatin C in Patients with Renal Transplantation

OBJECTIVE： To investigate the correlation of blood concentration of cyclosporine A （CsA） with cystatin C （CysC） and serum creatinine （Scr） in patients with renal transplantation. METHODS： The postoperative renal function of 118 pa- tients with renal transplantation was stable （Scr clearance〉40 ml/min, 60 male/58 female, a total of 307 cases）. The blood concen- tration of CsA, CysC and Scr were monitored after operation. RESULTS： As the extension of time, blood concentration of CsA showed a gradual declining trend, and average value of CysC was higher than normal reference range while Scr values were within the normal reference range. The blood concentrations of CsA were not significantly associated with CysC value and Scr in different positive time groups and different drug concentration groups. CONCLUSIONS： After renal transplantation, blood concentration of CsA has no effect on the evaluation of graft function by the biochemical indicators such as CvsC, Scr.