B[a]P所致神经发育毒性的研究进展

B[a]P（benzo[a]pyrene,B[a]P）是重要的职业和环境污染物之一,它的神经发育毒性与致癌性／致畸性相比虽是一种弱效应,但会对处于发育中的机体造成不良后果,尤其是中枢神经系统对其更为敏感。本课题组以近年来国内外有关B[a]P神经发育毒性的研究为基础,综述其流行病学研究、实验动物研究以及可能的毒性机制等方面研究进展;结合本课题组的已有研究,认为由于B[a]P的神经发育毒性所致学习和记忆损伤应得到广泛关注。

Advancement in Research of Benzo[a]pyrene Toxicity on Neurodevelopment

Benzo[a]pyrene（B[a]P） is one of the most important occupational and environmental contaminants.Compared with its carcinogenicity and teratogenicity,its toxicity on neurodevelopment is a weak effect,but could cause serious and adverse consequences for the developing individuals,especially for the central nervous system,which is a very sensitive target.In this paper,based on the research progresses of B[a]P toxicity on neurodevelopment at home and abroad,we summarized the epidemiological studies,neurotoxicity in animal models,and plausible mechanism due to B[a]P exposure.Combined with our previous study,more attention should be paid to the damage to learning and memory by B[a]P exposure.