Mice genetically selected for differences in open-field activity after ethanol |
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Authors: | J C Crabbe E R Young C M Deutsch B R Tam A Kosobud |
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Institution: | Department of Medical Psychology, Oregon Health Sciences University, Portland. |
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Abstract: | Starting from a population of genetically heterogeneous mice, selective breeding is being used to develop lines differing in sensitivity to ethanol-induced open-field activity. Mice are tested twice for 4 min in an open field. The first test is between min 2-6 after injection of saline. Twenty-four hr later, a similar test is performed after injection of ethanol (1.5 g/kg). Two independent FAST lines are being selected for ethanol-induced increases in activity, and two independent SLOW lines are being selected for ethanol-induced decreases. After four generations of selection, the lines have diverged significantly. These lines should be useful for exploring the neuropharmacological basis for the activating and rewarding properties of ethanol. |
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