| 肝细胞生长因子对癌细胞向血管内游走的影响 |
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| 引用本文： | 辛华,郑雅娟,韩振国,房德忠.肝细胞生长因子对癌细胞向血管内游走的影响[J].吉林大学学报(医学版),2004,30(4):589-590. |
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| 作者姓名： | 辛华 郑雅娟 韩振国 房德忠 |
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| 作者单位： | 1. 吉林大学中日联谊医院胸外科，吉林 长春130031；2. 吉林大学第二医院眼科，吉林 长春130041 |
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| 摘 要： | 目的：研究肝细胞生长因子(HGF)对癌细胞向血管内游走的影响。
方法：利用体外癌细胞向血管内游走模型，将纤维肉瘤细胞HT1080经过荧光标记，通过测定不同时间穿过胶原层及HUVEC单细胞层落到24孔板内的荧光量来定量评价瘤细胞血管内的游走情况。结果：作用12、24和48 h时，加HGF组的荧光量均明显高于未加HGF对照组(P<0.01)。结论：HGF能够增强癌细胞的运动能力，加速癌细胞向血管内迁移。
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| 关 键 词： | 肿瘤转移 血管内游走 |
| 文章编号： | 1671-587X(2004)04-0589-02 |
| 收稿时间： | 2003-04-24 |
| 修稿时间： | 2003年4月24日 |
Effects of hepatocyte growth factor on intravasation migration of cancer cell |
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| XIN Hua,ZHENG Ya-juan,HAN Zhen-guo,FANG De-zhong.Effects of hepatocyte growth factor on intravasation migration of cancer cell[J].Journal of Jilin University: Med Ed,2004,30(4):589-590. |
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| Authors: | XIN Hua ZHENG Ya-juan HAN Zhen-guo FANG De-zhong |
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| Institution: | 1. Department of Thoracic Surgery, China-Japan Union Hospital, Jilin University, Changchun 130031, China;2. Department of Ophthalmology, Second Hospital, Jilin University, Changchun 130041, China |
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| Abstract: | Objective To evaluate the effects of hepatocyte growth factor(HGF) on intravasation migration of cancer cell. Methods The model of intravasation migration of cancer cell in vitro was used. The fibrosarcoma cell HT1080 was labelled with fluorescence, and the fluorescence guantities in 24-pore plate through collagen membrane and HUVEC single cells layer were detected in different time to eveluate the intravasation migration of cancer cell.Results 12,24, and 48 hours after administration,the fluorescence quantity in experimental group was significantly higher than that in control group (P<0.01). Conclusion HGF can promote the intravasation migration of cancer cells. |
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| Keywords: | hepatocyte growth factor neoplasm metastasis intravasation migration |
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