Biomarkers in Neurocritical Care |
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Authors: | Email author" target="_blank">W?Taylor?KimberlyEmail author |
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Institution: | 1.Department of Neurology, Division of Neurocritical Care and Emergency Neurology,Massachusetts General Hospital,Boston,USA |
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Abstract: | The gold standard for assessing neurological function is the bedside clinical examination. However, in neurocritical patients,
the signs and symptoms related to the severity of illness can often be ambiguous. It can be hard to distinguish between a
severe but stable disease state and one that is dynamic and in a critical decline. Clinicians and family members alike may
struggle with the uncertainty of functional outcome prediction. Intermediate biomarkers of brain injury can assist with ongoing
clinical management of patients, and in some circumstances can guide prognosis. Used in the right setting, biomarkers in neurocritical
care can also aid with decisions to intensify treatment or avoid prolonged and unnecessary therapy. The term biomarker is
used in various ways, and here we use it to refer to 3 general types: 1) circulating blood macromolecules, 2) brain imaging,
and 3) continuous invasive monitors. Despite its promise, biomarkers have several limitations and should be interpreted in
the context of the overall clinical assessment. |
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Keywords: | |
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