| 尖锐湿疣组织中Bcl-2和Bax蛋白的检测和意义 |
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| 引用本文： | 尹光文,赵卫华,于建斌,张云汉,高冬玲,傅世珍.尖锐湿疣组织中Bcl-2和Bax蛋白的检测和意义[J].中国皮肤性病学杂志,2005,19(10):586-587. |
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| 作者姓名： | 尹光文 赵卫华 于建斌 张云汉 高冬玲 傅世珍 |
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| 作者单位： | 1. 郑州大学第一附属医院皮肤性病科,河南,郑州,450052
2. 郑州大学第一附属医院病理科,河南省肿瘤病理重点实验室,河南,郑州,450052 |
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| 摘 要： | 目的了解Bcl2和Bax蛋白在尖锐湿疣发病中的作用。方法用免疫组化SP法分别检测28例CA组织和14例正常上皮组织中Bcl2和Bax蛋白。结果Bcl2蛋白在28例CA组织中阳性率为46.43%,在14例正常上皮阳性率为14.29%,两者比较差异有显著性(P<0.01);28例CA组织中Bax蛋白阳性率75.00%,而14例正常上皮中阳性率57.14%,两组阳性率差异无显著性(P>0.05);Bcl2和Bax之间呈负相关(r=-0.611,P<0.05)。结论Bcl2和Bax可能与CA的发病有一定关系。
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| 关 键 词： | Bcl-2 Bax 尖锐湿疣 细胞凋亡 |
| 文章编号： | 1001-7089（2005）10-0586-02 |
| 收稿时间： | 2005-05-10 |
| 修稿时间： | 2005-05-102005-07-30 |
Detection and Significance of Bcl-2 and Bax Protein in Condyloma Acuminata |
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| YIN Guang-wen ,ZHAO Wei-hua, Y U Jian-bin,et al.Detection and Significance of Bcl-2 and Bax Protein in Condyloma Acuminata[J].The Chinese Journal of Dermatovenereology,2005,19(10):586-587. |
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| Authors: | YIN Guang-wen ZHAO Wei-hua Y U Jian-bin |
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| Institution: | Department of Dermatology and Venerology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China |
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| Abstract: | Objective To detect Bcl-2 and Bax protein in keratinocytes of Condyloma acuminatum(CA),and to explore their roles in pathogenesis.Methods Bcl-2 and Bax protein in 28 cases of CA and 14 normal controls were detected respectively by immunohistochemistry staining(SP).Results Bcl-2 in CA were significantly higher than those in normal samples(P<0.01),and there was a negative correlation between Bcl-2 and Bax(r= -0.611,P<0.05). Conclusion Bcl-2 and Bax in CA may play some roles in CA pathogenesis. |
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| Keywords: | Bcl-2 Bax Condyloma acuminatum Apoptosis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
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