| 非霍奇金淋巴瘤组织p53和p21ras的表达及其临床意义 |
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| 引用本文： | 徐锦屏. 非霍奇金淋巴瘤组织p53和p21ras的表达及其临床意义[J]. 中华肿瘤防治杂志, 2004, 11(3): 289-290 |
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| 作者姓名： | 徐锦屏 |
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| 作者单位： | 台州市中心医院病理科,浙江,台州,318000 |
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| 摘 要： | 目的 :研究非霍奇金淋巴瘤(non Hodgkin’slymphoma ,NHL )中 p5 3和p2 1ras蛋白的表达情况及相关性。 方法 :应用免疫组化法检测 5 8例NHL的 p5 3和p2 1ras蛋白表达情况 ,并作相关性分析。结果 :5 8例NHL中 ,阳性表达率 p5 3蛋白为 62 1%( 3 6/5 8) ,p2 1ras蛋白为 5 6 9% ( 3 3 /5 8)。p5 3蛋白在低度及高度恶性组表达率为 2 9 2 %( 7/2 4)和 85 3 % ( 2 9/3 4) ,P <0 0 5。p2 1ras蛋白在低度及高度恶性组表达率 2 0 8%( 5 /2 4)和 82 4% ( 2 8/3 4) ,P <0 0 1。结论 :在NHL发展中 ,p5 3和p2 1ras蛋白的高表达起着重要作用
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| 关 键 词： | 蛋白质p53 癌基因蛋白质p21(ras) 淋巴瘤 非霍奇金氏/病理学 免疫组织化学 |
| 文章编号： | 1009-4571(2004)03-0289-02 |
| 修稿时间： | 2002-10-21 |
Expression and diagnostic value of p53 and p21ras in non-Hodgkin''''s lymphoma |
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| XU Jin-ping. Expression and diagnostic value of p53 and p21ras in non-Hodgkin''''s lymphoma[J]. Chinese Journal of Cancer Prevention and Treatment, 2004, 11(3): 289-290 |
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| Authors: | XU Jin-ping |
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| Affiliation: | XU Jin-ping Department of Pathology,Taizhou City Central Hospital,Taizhou 318000,P.R.China |
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| Abstract: | OBJECTIVE:To study the expression and diagnostic value of p53 and p21ras in non-Hodgkin's lymphoma (NHL).METHODS Fifty-eight cases of NHL were examined by the immunohistochemial two-step-system method for p53 and p21ras.RESULTS The positive rates of p53 and p21ras were 62.1%(36/58) and 56.9%(33/58) respectively.The positive rates of p53 in well differentated lymphomas and poorly differentated lymphomas were 29.2%(7/24) and 85.3%(29/34),P<0.05.The positive rates of p21ras in well differentated lymphomas and poorly differentated lymphomas were 20.8%(5/24) and 82.4%(28/34),P<0.01.CONCLUSIONS The over expression of p53 and p21ras may play an important role in the development of NHL. |
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| Keywords: | protein p53 oncogene protein p21(ras) lymphoma non-Hodgkin/pathology immunohistochemistry |
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